How do cryptosporidia establish their unique niche within the host epithelium?

Kód výsledku v IS VaVaI

RIV/00216224:14310/09:00037136 - isvavai.cz

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

How do cryptosporidia establish their unique niche within the host epithelium?

Popis výsledku v původním jazyce

Cryptosporidia are significant vertebrate pathogens with unique invasion strategy, which, together with phylogenetic analyses suggest a close affinity to gregarines. Electron microscopic observations on 2 evolutionarily distinct gastric species, Cryptosporidium muris from experimentally infected rodents and C. fragile from naturally infected toads, allowed us to map ultrastructural aspects of the cryptosporidian invasion process along with the origin and architecture of parasitophorous sac, and to generalize these observations for gastric cryptosporidia. Both species exhibit a comparable strategy of host cell invasion in which they do not penetrate under the host cell plasma membrane, nor do they come into close contact with the host cytoplasm. Parasite remains attached to the host cell surface, only enveloped by the host membrane folds. Thus, the term epicellular more accurately defines the host compartment within which cryptosporidia reside than does the term intracellular-extracytop

Název v anglickém jazyce

How do cryptosporidia establish their unique niche within the host epithelium?

Popis výsledku anglicky

Cryptosporidia are significant vertebrate pathogens with unique invasion strategy, which, together with phylogenetic analyses suggest a close affinity to gregarines. Electron microscopic observations on 2 evolutionarily distinct gastric species, Cryptosporidium muris from experimentally infected rodents and C. fragile from naturally infected toads, allowed us to map ultrastructural aspects of the cryptosporidian invasion process along with the origin and architecture of parasitophorous sac, and to generalize these observations for gastric cryptosporidia. Both species exhibit a comparable strategy of host cell invasion in which they do not penetrate under the host cell plasma membrane, nor do they come into close contact with the host cytoplasm. Parasite remains attached to the host cell surface, only enveloped by the host membrane folds. Thus, the term epicellular more accurately defines the host compartment within which cryptosporidia reside than does the term intracellular-extracytop

Druh

O - Ostatní výsledky

CEP obor

EG - Zoologie

OECD FORD obor

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Projekt

LC522: ICHTYOPARAZITOLOGIE - centrum základního výzkumu

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Z - Vyzkumny zamer (s odkazem do CEZ)
S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů