Nature of lectin carbohydrate interactions and how to treat them by computational chemistry tools

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F09%3A00038060" target="_blank" >RIV/00216224:14310/09:00038060 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Nature of lectin carbohydrate interactions and how to treat them by computational chemistry tools

Popis výsledku v původním jazyce

Recognition in biological systems is often mediated through protein/carbohydrate interactions. Proteins that bind carbohydrates are called lectins. As the number of combinations that may create the saccharide code is extremely large, lectins must be verycarefully designed by Nature to read and decipher such a complicated alphabet. The key role during the process of such deciphering is played by protein/carbohydrate interaction energy. The forces that keep lectin/carbohydrate complexes together are based either on polar interactions between the polar carbohydrate groups, represented especially by oxygen atoms, and polar protein functional groups. This kind of interactions may often be mediated or enlarged by bridging water molecules, or by ions. The last option usually generates strong interactions leading to stable lectin/carbohydrate complexes.

Název v anglickém jazyce

Nature of lectin carbohydrate interactions and how to treat them by computational chemistry tools

Popis výsledku anglicky

Recognition in biological systems is often mediated through protein/carbohydrate interactions. Proteins that bind carbohydrates are called lectins. As the number of combinations that may create the saccharide code is extremely large, lectins must be verycarefully designed by Nature to read and decipher such a complicated alphabet. The key role during the process of such deciphering is played by protein/carbohydrate interaction energy. The forces that keep lectin/carbohydrate complexes together are based either on polar interactions between the polar carbohydrate groups, represented especially by oxygen atoms, and polar protein functional groups. This kind of interactions may often be mediated or enlarged by bridging water molecules, or by ions. The last option usually generates strong interactions leading to stable lectin/carbohydrate complexes.

Druh

D - Stať ve sborníku

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/LC06030" target="_blank" >LC06030: Biomolekulární centrum</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Glycoconjugate Journal, "20th International Symposium on Glycoconjugates Glycans: From Molecules to Structures to Therapeutics, San Juan, Puerto Rico.

ISBN

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ISSN

0282-0080

e-ISSN

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Počet stran výsledku

1

Strana od-do

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Název nakladatele

Springer

Místo vydání

Netherlands

Místo konání akce

San Juan, Puerto Rico

Datum konání akce

1. 1. 2009

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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