Thermodynamic and kinetic studies of lanthanide(III) complexes with mono(pyridine-N-oxide) analog of DOTA

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F09%3A00042951" target="_blank" >RIV/00216224:14310/09:00042951 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Thermodynamic and kinetic studies of lanthanide(III) complexes with mono(pyridine-N-oxide) analog of DOTA

Popis výsledku v původním jazyce

Ln(III) complexes of H4dota and its derivatives are utilized in many areas of medicine (e.g. complexes of metal radioisotopes as 90Y, 153Sm, 166Ho, 177Lu in nuclear medicine, Gd(III) complexes as MRI contrast agents, Eu(III) or Tb(III) complexes as luminescent probes). In this contribution, the thermodynamic and kinetic properties of Y(III) and Ln(III) complexes (Ln = Ce, Eu, Gd, Yb) of the mono(pyridine-N-oxide) H4dota derivative were studied by molecular absorption and emission spectroscopies (in UV/VIS region, luminescence, TRFS). The mechanisms of complex formation (pH = 5.0-6.0, t = 25 degrees of Celsius, I = 0.1 M KCl) and acid-assisted complex dissociation (t = 25-70 degrees of Celsius, I = 3.0 M (Na,H)ClO4) were proposed. Achieved results can be used for fluorimetric determination of Ln(III) ions in mixture.

Název v anglickém jazyce

Thermodynamic and kinetic studies of lanthanide(III) complexes with mono(pyridine-N-oxide) analog of DOTA

Popis výsledku anglicky

Ln(III) complexes of H4dota and its derivatives are utilized in many areas of medicine (e.g. complexes of metal radioisotopes as 90Y, 153Sm, 166Ho, 177Lu in nuclear medicine, Gd(III) complexes as MRI contrast agents, Eu(III) or Tb(III) complexes as luminescent probes). In this contribution, the thermodynamic and kinetic properties of Y(III) and Ln(III) complexes (Ln = Ce, Eu, Gd, Yb) of the mono(pyridine-N-oxide) H4dota derivative were studied by molecular absorption and emission spectroscopies (in UV/VIS region, luminescence, TRFS). The mechanisms of complex formation (pH = 5.0-6.0, t = 25 degrees of Celsius, I = 0.1 M KCl) and acid-assisted complex dissociation (t = 25-70 degrees of Celsius, I = 3.0 M (Na,H)ClO4) were proposed. Achieved results can be used for fluorimetric determination of Ln(III) ions in mixture.

Druh

O - Ostatní výsledky

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

<a href="/cs/project/ME09065" target="_blank" >ME09065: Výzkum nových detekčních systémů na bázi senzorových polí pro použití ve speciační analýze</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů