Expression of hippocampal NMDA receptor GluN1 subunit and its splicing isoforms in schizophrenia: postmortem study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F10%3A00040731" target="_blank" >RIV/00216224:14310/10:00040731 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Expression of hippocampal NMDA receptor GluN1 subunit and its splicing isoforms in schizophrenia: postmortem study

Popis výsledku v původním jazyce

There is accumulating evidence that disturbances in the N-methyl-D-aspartate receptor (NMDA-R) functioning are associated with the pathogenesis of schizophrenia. To assess actual changes in the expression of the GluN1 subunit and its isoforms, we measured absolute differences in the levels of mRNA/protein for panGluN1 (8 isoforms altogether) as well as the mRNA individual isoforms in the post-mortem left/right hippocampus of patients with schizophrenia in comparison with non-psychiatric subjects. Therewere no significant differences in the panGluN1subunit mRNA expression, but the absolute left-right differences were much more pronounced in the patients with schizophrenia. Protein levels of the GluN1 subunit in the left hippocampus in male schizophrenic patients were lower in comparison with controls. The expression of the NR1-4b isoform was attenuated in the left whereas the NR1-2b was reduced in the right hippocampus of schizophrenic patients.

Název v anglickém jazyce

Expression of hippocampal NMDA receptor GluN1 subunit and its splicing isoforms in schizophrenia: postmortem study

Popis výsledku anglicky

There is accumulating evidence that disturbances in the N-methyl-D-aspartate receptor (NMDA-R) functioning are associated with the pathogenesis of schizophrenia. To assess actual changes in the expression of the GluN1 subunit and its isoforms, we measured absolute differences in the levels of mRNA/protein for panGluN1 (8 isoforms altogether) as well as the mRNA individual isoforms in the post-mortem left/right hippocampus of patients with schizophrenia in comparison with non-psychiatric subjects. Therewere no significant differences in the panGluN1subunit mRNA expression, but the absolute left-right differences were much more pronounced in the patients with schizophrenia. Protein levels of the GluN1 subunit in the left hippocampus in male schizophrenic patients were lower in comparison with controls. The expression of the NR1-4b isoform was attenuated in the left whereas the NR1-2b was reduced in the right hippocampus of schizophrenic patients.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

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Projekt

<a href="/cs/project/NR9324" target="_blank" >NR9324: Kandidátní geny pro schizofrenii: vliv na fenotypovou variabilitu nemocných a in vitro manipulace genové exprese pomocí siRNA.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neurochemical Research

ISSN

0364-3190

e-ISSN

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Svazek periodika

2010

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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