The role of c-Myb in regulation of migration and invasivity of colon carcinoma cells

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The role of c-Myb in regulation of migration and invasivity of colon carcinoma cells

Popis výsledku v původním jazyce

c-Myb is a transcription factor expressed in immature hematopoietic cells and in various types of tumor cells, such as colon and breast carcinoma cells. It is implicated in control of proliferation, differentiation and apoptosis. Its function during migration and invasion remains unclear. The aim of this study is to assess the role of c-Myb in control of invasivity of colon cancer cells. To determine the effect of c-Myb on migration and invasion of CT26cMyb cells, we used the xCELLigence System that monitors a cell migration and invasivity continuously in real time. We showed that enhanced expression of c-Myb increased migration and invasivity of colon carcinoma CT26 cells. In addition, the proinvasive factor Slug was found up-regulated in c-Myb overexpressing CT26cMyb cells, suggesting that Myb uses this protein to control invasivity of colon carcinoma cells. This study demonstrates that c-Myb has an important role in the regulation of migration and invasion of cancer cells.

Název v anglickém jazyce

The role of c-Myb in regulation of migration and invasivity of colon carcinoma cells

Popis výsledku anglicky

c-Myb is a transcription factor expressed in immature hematopoietic cells and in various types of tumor cells, such as colon and breast carcinoma cells. It is implicated in control of proliferation, differentiation and apoptosis. Its function during migration and invasion remains unclear. The aim of this study is to assess the role of c-Myb in control of invasivity of colon cancer cells. To determine the effect of c-Myb on migration and invasion of CT26cMyb cells, we used the xCELLigence System that monitors a cell migration and invasivity continuously in real time. We showed that enhanced expression of c-Myb increased migration and invasivity of colon carcinoma CT26 cells. In addition, the proinvasive factor Slug was found up-regulated in c-Myb overexpressing CT26cMyb cells, suggesting that Myb uses this protein to control invasivity of colon carcinoma cells. This study demonstrates that c-Myb has an important role in the regulation of migration and invasion of cancer cells.

Druh

D - Stať ve sborníku

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

The Student Scientific Conference on Cancer Research

ISBN

978-80-210-5442-4

ISSN

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e-ISSN

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Počet stran výsledku

2

Strana od-do

110-111

Název nakladatele

Neuveden

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

1. 1. 2011

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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