POTENTIOMETRIC AND VOLTAMMETRIC STUDY OF 6 ? BENZYLAMINOPURINE AND ITS DERIVATIVES

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00052408" target="_blank" >RIV/00216224:14310/11:00052408 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

POTENTIOMETRIC AND VOLTAMMETRIC STUDY OF 6 ? BENZYLAMINOPURINE AND ITS DERIVATIVES

Popis výsledku v původním jazyce

Benzylaminopurine (6?BAP),as the derivative of adenine,is involved among cytokinins (CKs).CKs are phytohormones which participate in regulation of growth and development processes of plants. Methoxy and chlorine derivatives of 6-BAP show antitumor activity (inhibitors of cyclin?dependent kinases) and due to this effect may be considered as potential cytostatics.The aim of this contribution is the determination of protonation constants of 6?BAP and its derivatives by potentiometric method for the different experimental conditions,such as methanol content (2.5-20 v/v percentages),temperature (5-37C) and ionic strength (I=0.1-1M NaCl).To determine the thermodynamic parameters deltaH and deltaS the temperature dependence of pKa was employed.The effect of the position of methoxy and chlorine group (X is Cl or OCH3) in 2',3'and 4'on benzene ring of 6?BAP was studied,too.

Název v anglickém jazyce

POTENTIOMETRIC AND VOLTAMMETRIC STUDY OF 6 ? BENZYLAMINOPURINE AND ITS DERIVATIVES

Popis výsledku anglicky

Benzylaminopurine (6?BAP),as the derivative of adenine,is involved among cytokinins (CKs).CKs are phytohormones which participate in regulation of growth and development processes of plants. Methoxy and chlorine derivatives of 6-BAP show antitumor activity (inhibitors of cyclin?dependent kinases) and due to this effect may be considered as potential cytostatics.The aim of this contribution is the determination of protonation constants of 6?BAP and its derivatives by potentiometric method for the different experimental conditions,such as methanol content (2.5-20 v/v percentages),temperature (5-37C) and ionic strength (I=0.1-1M NaCl).To determine the thermodynamic parameters deltaH and deltaS the temperature dependence of pKa was employed.The effect of the position of methoxy and chlorine group (X is Cl or OCH3) in 2',3'and 4'on benzene ring of 6?BAP was studied,too.

Druh

O - Ostatní výsledky

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/LC06035" target="_blank" >LC06035: Centrum biofyzikální chemie, bioelektrochemie a bioanalýzy. Nové nástroje pro genomiku, proteomiku a biomedicínu.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů