Solution Behavior of DOTP Analogs and Their Lanthanide(III) Complexes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00054681" target="_blank" >RIV/00216224:14310/11:00054681 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Solution Behavior of DOTP Analogs and Their Lanthanide(III) Complexes

Popis výsledku v původním jazyce

Complexes of trivalent lanthanides are utilized in medicine and preclinical research as magnetic resonance, optical or nuclear probes. In this contribution, thermodynamic (ligand dissociation and complex stability constants) and kinetic (formation and dissociation) properties of selected lanthanide(III) complexes with phosphorus-containing macrocyclic ligand which are based on cyclen skeleton will be presented. The ligands are H8dotp analogs where substituents modified on all parent phosphonate groups are monoester (H4dotpOEt), phosphinate (H4dotpH) or phenylphosphinate (H4dotpPh). The H8dotp analogs are less basic then the mother ligand and, consequently, the thermodynamic stabilities of the lanthanide(III) complexes are much lower. Rates of the complex formation of studied ligands are of the same order of magnitude to that for H8dotp. Kinetic inertness of complexes of the anologs is mostly lower; however, the kinetic inerteness is still much higher than that of complexes of open-chai

Název v anglickém jazyce

Solution Behavior of DOTP Analogs and Their Lanthanide(III) Complexes

Popis výsledku anglicky

Complexes of trivalent lanthanides are utilized in medicine and preclinical research as magnetic resonance, optical or nuclear probes. In this contribution, thermodynamic (ligand dissociation and complex stability constants) and kinetic (formation and dissociation) properties of selected lanthanide(III) complexes with phosphorus-containing macrocyclic ligand which are based on cyclen skeleton will be presented. The ligands are H8dotp analogs where substituents modified on all parent phosphonate groups are monoester (H4dotpOEt), phosphinate (H4dotpH) or phenylphosphinate (H4dotpPh). The H8dotp analogs are less basic then the mother ligand and, consequently, the thermodynamic stabilities of the lanthanide(III) complexes are much lower. Rates of the complex formation of studied ligands are of the same order of magnitude to that for H8dotp. Kinetic inertness of complexes of the anologs is mostly lower; however, the kinetic inerteness is still much higher than that of complexes of open-chai

Druh

O - Ostatní výsledky

CEP obor

CA - Anorganická chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/ME09065" target="_blank" >ME09065: Výzkum nových detekčních systémů na bázi senzorových polí pro použití ve speciační analýze</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů