Amplification of hTERC (3q26) and MYCC (8q24) genes in correlation with oncogenic human papilloma virus infection in cervical cancer
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00055260" target="_blank" >RIV/00216224:14310/11:00055260 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Amplification of hTERC (3q26) and MYCC (8q24) genes in correlation with oncogenic human papilloma virus infection in cervical cancer
Popis výsledku v původním jazyce
Cervical cancer remains one of the most common malignancies among women worldwide in both incidence and mortality. Several premalignant stages can be distinguished in the development of invasive carcinoma, including cervical intraepithelial neoplasia grades I-III (CIN I?III). The genetic basis of progression of CIN I to CIN II/III and to invasive carcinoma remain poorly understood. Although infection of high-risk human papilloma virus (HPV) is recognized as an essential initiating event in cervical tumorigenesis, this alone is not sufficient for the progression to invasive cancer. Some chromosomal aberrations have been associated with the progression of CIN to carcinoma, especially the amplification of the human telomerase gene hTERC (3q26) and protooncogene MYCC (8q24).
Název v anglickém jazyce
Amplification of hTERC (3q26) and MYCC (8q24) genes in correlation with oncogenic human papilloma virus infection in cervical cancer
Popis výsledku anglicky
Cervical cancer remains one of the most common malignancies among women worldwide in both incidence and mortality. Several premalignant stages can be distinguished in the development of invasive carcinoma, including cervical intraepithelial neoplasia grades I-III (CIN I?III). The genetic basis of progression of CIN I to CIN II/III and to invasive carcinoma remain poorly understood. Although infection of high-risk human papilloma virus (HPV) is recognized as an essential initiating event in cervical tumorigenesis, this alone is not sufficient for the progression to invasive cancer. Some chromosomal aberrations have been associated with the progression of CIN to carcinoma, especially the amplification of the human telomerase gene hTERC (3q26) and protooncogene MYCC (8q24).
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů