Docosahexaenoic acid sensitizes colon cancer cells to apoptotic effect of TRAIL by modulation of lipid and apoptotic signalling pathways
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00062482" target="_blank" >RIV/00216224:14310/11:00062482 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.chemphyslip.2011.05.106" target="_blank" >http://dx.doi.org/10.1016/j.chemphyslip.2011.05.106</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.chemphyslip.2011.05.106" target="_blank" >10.1016/j.chemphyslip.2011.05.106</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Docosahexaenoic acid sensitizes colon cancer cells to apoptotic effect of TRAIL by modulation of lipid and apoptotic signalling pathways
Popis výsledku v původním jazyce
Recently, it is suggested that some dietary polyunsaturated fatty acids (PUFAs) play an important role in suppression of colon cancer. Namely n-3 PUFAs, such as docosahexaenoic acid (DHA), showed antiproliferative and apoptotic effects in colon cancer cells. However, DHA is preferentially considered as supporting agent in combined anticancer therapy. TNF-related Apoptosis Inducing Ligand (TRAIL) is cytokine able to induce apoptosis in cancer cells with little effect on normal cells. It is promising forcancer treatment, but some cancer cells appeared to be resistant to TRAIL-induced apoptosis. We showed that pretreatment with physiological doses of DHA results in significantly enhanced TRAIL-induced apoptosis of otherwise resistant human colon cells asdocumented by increased caspase activation and cleavage of their substrates. We demonstrated activation of crucial mitochondrial proapototic molecules, such as Bax and Bak.
Název v anglickém jazyce
Docosahexaenoic acid sensitizes colon cancer cells to apoptotic effect of TRAIL by modulation of lipid and apoptotic signalling pathways
Popis výsledku anglicky
Recently, it is suggested that some dietary polyunsaturated fatty acids (PUFAs) play an important role in suppression of colon cancer. Namely n-3 PUFAs, such as docosahexaenoic acid (DHA), showed antiproliferative and apoptotic effects in colon cancer cells. However, DHA is preferentially considered as supporting agent in combined anticancer therapy. TNF-related Apoptosis Inducing Ligand (TRAIL) is cytokine able to induce apoptosis in cancer cells with little effect on normal cells. It is promising forcancer treatment, but some cancer cells appeared to be resistant to TRAIL-induced apoptosis. We showed that pretreatment with physiological doses of DHA results in significantly enhanced TRAIL-induced apoptosis of otherwise resistant human colon cells asdocumented by increased caspase activation and cleavage of their substrates. We demonstrated activation of crucial mitochondrial proapototic molecules, such as Bax and Bak.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
ED - Fyziologie
OECD FORD obor
—
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů