TGF-beta 1-Induced EMT of Non-Transformed Prostate Hyperplasia Cells Is Characterized by Early Induction of SNAI2/Slug
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00081795" target="_blank" >RIV/00216224:14310/11:00081795 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1002/pros.21350" target="_blank" >http://dx.doi.org/10.1002/pros.21350</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/pros.21350" target="_blank" >10.1002/pros.21350</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
TGF-beta 1-Induced EMT of Non-Transformed Prostate Hyperplasia Cells Is Characterized by Early Induction of SNAI2/Slug
Popis výsledku v původním jazyce
BACKGROUND. Epithelial mesenchymal transition (EMT) underlying cancer cell invasion and metastasis has been thoroughly studied in prostate cancer. Although EMT markers have been clinically observed in benign prostate hyperplasia, molecular events underlying the onset and progression of EMT in benign prostate cells have not been described. METHODS. EMT in BPH-1 cells was induced by TGF-beta 1 treatment and the kinetics of expression of EMT markers, regulators, and selected miRNAs was assessed by westernblotting and quantitative RT-PCR. RESULTS. EMT in BPH-1 cells was accompanied by rapid up-regulation of SNAI2/Slug and ZEB1 transcription factors, while changes in expression levels of ZEB2 and miR-200 family members were observed after extended time intervals.
Název v anglickém jazyce
TGF-beta 1-Induced EMT of Non-Transformed Prostate Hyperplasia Cells Is Characterized by Early Induction of SNAI2/Slug
Popis výsledku anglicky
BACKGROUND. Epithelial mesenchymal transition (EMT) underlying cancer cell invasion and metastasis has been thoroughly studied in prostate cancer. Although EMT markers have been clinically observed in benign prostate hyperplasia, molecular events underlying the onset and progression of EMT in benign prostate cells have not been described. METHODS. EMT in BPH-1 cells was induced by TGF-beta 1 treatment and the kinetics of expression of EMT markers, regulators, and selected miRNAs was assessed by westernblotting and quantitative RT-PCR. RESULTS. EMT in BPH-1 cells was accompanied by rapid up-regulation of SNAI2/Slug and ZEB1 transcription factors, while changes in expression levels of ZEB2 and miR-200 family members were observed after extended time intervals.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
ED - Fyziologie
OECD FORD obor
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Návaznosti výsledku
Projekt
—
Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Prostate
ISSN
0270-4137
e-ISSN
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Svazek periodika
71
Číslo periodika v rámci svazku
12
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
12
Strana od-do
1332-1343
Kód UT WoS článku
000294443600010
EID výsledku v databázi Scopus
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