Supramolecular complexes formation. Possibilities of mass spectrometric studies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F12%3A00059907" target="_blank" >RIV/00216224:14310/12:00059907 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.euchems-prague2012.cz/" target="_blank" >http://www.euchems-prague2012.cz/</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Supramolecular complexes formation. Possibilities of mass spectrometric studies

Popis výsledku v původním jazyce

In supramolecular complexes the molecules or ions are held together by non-covalent interactions: Host + Guest &lt;=&gt; {Host, Guest}. Usually, compounds like cyclic ethers, cyclodextrines, or other macrocycles might act as hosts while various organic/inorganic cations, anions, neutral molecules etc. are playing the role of guests. The paper deals with the application of mass spectrometry (MS) for fast screening of variour host-guests combinations in order to find out the formation of supramolecular complexes and/or to search for new potential drug carriers or to decrease their toxicity. MS was done using either matrices, laser desorption ionization (LDI) or surface assisted LDI. Mass spectrometric analysis was used because the reactions can also be done directly on the MS target and several combinations can be examined with the minimum amount of often scarce and expensive reagents.

Název v anglickém jazyce

Supramolecular complexes formation. Possibilities of mass spectrometric studies

Popis výsledku anglicky

In supramolecular complexes the molecules or ions are held together by non-covalent interactions: Host + Guest &lt;=&gt; {Host, Guest}. Usually, compounds like cyclic ethers, cyclodextrines, or other macrocycles might act as hosts while various organic/inorganic cations, anions, neutral molecules etc. are playing the role of guests. The paper deals with the application of mass spectrometry (MS) for fast screening of variour host-guests combinations in order to find out the formation of supramolecular complexes and/or to search for new potential drug carriers or to decrease their toxicity. MS was done using either matrices, laser desorption ionization (LDI) or surface assisted LDI. Mass spectrometric analysis was used because the reactions can also be done directly on the MS target and several combinations can be examined with the minimum amount of often scarce and expensive reagents.

Druh

O - Ostatní výsledky

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů