Multidrug resistance-associated ABC transporters ? too much of one thing, good for nothing

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F12%3A00063603" target="_blank" >RIV/00216224:14310/12:00063603 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.degruyter.com/view/j/bmc" target="_blank" >http://www.degruyter.com/view/j/bmc</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/bmc-2012-0006" target="_blank" >10.1515/bmc-2012-0006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Multidrug resistance-associated ABC transporters ? too much of one thing, good for nothing

Popis výsledku v původním jazyce

Overexpression of ATP-binding cassette (ABC) transporters in cancer cells results in multidrug resistance (MDR) which leads to unsuccessful chemotherapy. The most important MDR-associated members of ABC superfamily are ABC B1/P-glycoprotein/MDR1, ABC C1/multidrug resistance associated protein 1 (MRP1), and ABC G2/BCRP. This study is not only focused on function, substrates, and localization of these popular proteins but also on other ABC C family members such as ABC C2?6/MRP2-6 and ABC C7/CFTR. Currentresearch is mainly oriented on the cancer-promoting role of these proteins, but important lessons could also be learned from the physiological roles of these proteins or from polymorphisms affecting their function. Thorough knowledge of structure and detailed mechanism of efflux can aid in the discovery of new chemotherapy targets in the future.

Název v anglickém jazyce

Multidrug resistance-associated ABC transporters ? too much of one thing, good for nothing

Popis výsledku anglicky

Overexpression of ATP-binding cassette (ABC) transporters in cancer cells results in multidrug resistance (MDR) which leads to unsuccessful chemotherapy. The most important MDR-associated members of ABC superfamily are ABC B1/P-glycoprotein/MDR1, ABC C1/multidrug resistance associated protein 1 (MRP1), and ABC G2/BCRP. This study is not only focused on function, substrates, and localization of these popular proteins but also on other ABC C family members such as ABC C2?6/MRP2-6 and ABC C7/CFTR. Currentresearch is mainly oriented on the cancer-promoting role of these proteins, but important lessons could also be learned from the physiological roles of these proteins or from polymorphisms affecting their function. Thorough knowledge of structure and detailed mechanism of efflux can aid in the discovery of new chemotherapy targets in the future.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomolecular concepts

ISSN

1868-5021

e-ISSN

—

Svazek periodika

3

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

13

Strana od-do

319-331

Kód UT WoS článku

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EID výsledku v databázi Scopus

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