Do cyanobacteria produce estrogenic compounds?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F12%3A00067012" target="_blank" >RIV/00216224:14310/12:00067012 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Do cyanobacteria produce estrogenic compounds?

Popis výsledku v původním jazyce

Number of studies document hazardous potential of cyanobacterial metabolites.Despite the observed effects on reproduction related parameters, growth and development,there is little information on endocrine disruptive potential of compounds from cyanobacteria.Our research aimed to determine if complex water bloom of cyanobacteria collected from the environment contain compounds that would interact with the signaling pathways of arylhydrocarbon receptor (AhR), androgenic receptor (AR), estrogenic receptor(ER),glucocorticoid receptor (GR) or retinoid acid receptor (RAR).In vitro reporter gene trans-activation assays were used to determine the potency of samples to elicit receptor-mediated responses.Estrogenicity was detected for most environmental samples, their estimated estrogenic equivalents ranged from 19 to 2200 ng 17b-estradiol /g dw.Some of them also interfered with the signalling of androgen receptor.

Název v anglickém jazyce

Do cyanobacteria produce estrogenic compounds?

Popis výsledku anglicky

Number of studies document hazardous potential of cyanobacterial metabolites.Despite the observed effects on reproduction related parameters, growth and development,there is little information on endocrine disruptive potential of compounds from cyanobacteria.Our research aimed to determine if complex water bloom of cyanobacteria collected from the environment contain compounds that would interact with the signaling pathways of arylhydrocarbon receptor (AhR), androgenic receptor (AR), estrogenic receptor(ER),glucocorticoid receptor (GR) or retinoid acid receptor (RAR).In vitro reporter gene trans-activation assays were used to determine the potency of samples to elicit receptor-mediated responses.Estrogenicity was detected for most environmental samples, their estimated estrogenic equivalents ranged from 19 to 2200 ng 17b-estradiol /g dw.Some of them also interfered with the signalling of androgen receptor.

Druh

O - Ostatní výsledky

CEP obor

DJ - Znečištění a kontrola vody

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů