Development of a novel enzyme-linked immunosorbent assay (ELISA) for measurement of serum CTRP1 A pilot study: Measurement of serum CTRP1 in healthy donors and patients with metabolic syndrome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F13%3A00067579" target="_blank" >RIV/00216224:14310/13:00067579 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.clinbiochem.2012.09.006" target="_blank" >http://dx.doi.org/10.1016/j.clinbiochem.2012.09.006</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clinbiochem.2012.09.006" target="_blank" >10.1016/j.clinbiochem.2012.09.006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Development of a novel enzyme-linked immunosorbent assay (ELISA) for measurement of serum CTRP1 A pilot study: Measurement of serum CTRP1 in healthy donors and patients with metabolic syndrome

Popis výsledku v původním jazyce

Background: Complement C1q tumor necrosis factor-related protein 1 (CTRP1), a recently identified adipokine, was found to stimulate aldosterone production. Obesity and metabolic syndrome are frequently associated with elevated levels of aldosterone. Therefore, it would be interesting to investigate whether the secretion of CTRP1 in human serum is associated with obesity as well as with hypertension. Aim: This study evaluated serum CTRP1 concentrations in healthy individuals and patients with metabolic syndrome. Methods: Serum samples from 61 healthy individuals and 46 patients with metabolic syndrome were measured for CTRP1 by enzyme-linked immunosorbent assay (ELISA). Results: Correlation analyses showed that serum CTRP1 in healthy individuals did notcorrelate with BMI, leptin, TG, HDL-CH, and LDL-CH; however, in patients with metabolic syndrome, CTRP1 correlated with glucose, HbA1c and BMI. CTRP1 level was significantly higher in subjects with metabolic syndrome compared to healthy

Název v anglickém jazyce

Development of a novel enzyme-linked immunosorbent assay (ELISA) for measurement of serum CTRP1 A pilot study: Measurement of serum CTRP1 in healthy donors and patients with metabolic syndrome

Popis výsledku anglicky

Background: Complement C1q tumor necrosis factor-related protein 1 (CTRP1), a recently identified adipokine, was found to stimulate aldosterone production. Obesity and metabolic syndrome are frequently associated with elevated levels of aldosterone. Therefore, it would be interesting to investigate whether the secretion of CTRP1 in human serum is associated with obesity as well as with hypertension. Aim: This study evaluated serum CTRP1 concentrations in healthy individuals and patients with metabolic syndrome. Methods: Serum samples from 61 healthy individuals and 46 patients with metabolic syndrome were measured for CTRP1 by enzyme-linked immunosorbent assay (ELISA). Results: Correlation analyses showed that serum CTRP1 in healthy individuals did notcorrelate with BMI, leptin, TG, HDL-CH, and LDL-CH; however, in patients with metabolic syndrome, CTRP1 correlated with glucose, HbA1c and BMI. CTRP1 level was significantly higher in subjects with metabolic syndrome compared to healthy

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Biochemistry

ISSN

0009-9120

e-ISSN

—

Svazek periodika

46

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

73-78

Kód UT WoS článku

000313406800016

EID výsledku v databázi Scopus

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