The mechanism of response to hypoxia in embryonic stem cells
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F13%3A00070747" target="_blank" >RIV/00216224:14310/13:00070747 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The mechanism of response to hypoxia in embryonic stem cells
Popis výsledku v původním jazyce
Oxygen is a crucial element for life of most organisms. Key regulator of oxygen sensing and responding intracellular machinery is heterodimeric transcription factor HIF1 (hypoxia inducible factor 1). Presence of oxygen leads to rapid ubiquitination and proteozomal degradation of cytoplasmic subunit HIF1alpha. This process is abolished in hypoxia, leading to accumulation of alpha subunit and dimerization with HIF1beta (also called ARNT). Upon binding of HIF1 heterodimer to hypoxia responsive elements, transcription of many specific genes involved in oxygen homeostasis is induced (Wang et al., 1995). Moreover hypoxia increases a production of intracellular reactive oxygen species (ROS) (Chandel et al., 2002). ROS can modulate cell signaling through transcription and also through posttranslational modifications of intracellular signaling pathways (Finkel, 2011). Additionally, further mechanisms of low oxygen sensing excluding the involvement of HIF and ROS were reported (Wouters and Korit
Název v anglickém jazyce
The mechanism of response to hypoxia in embryonic stem cells
Popis výsledku anglicky
Oxygen is a crucial element for life of most organisms. Key regulator of oxygen sensing and responding intracellular machinery is heterodimeric transcription factor HIF1 (hypoxia inducible factor 1). Presence of oxygen leads to rapid ubiquitination and proteozomal degradation of cytoplasmic subunit HIF1alpha. This process is abolished in hypoxia, leading to accumulation of alpha subunit and dimerization with HIF1beta (also called ARNT). Upon binding of HIF1 heterodimer to hypoxia responsive elements, transcription of many specific genes involved in oxygen homeostasis is induced (Wang et al., 1995). Moreover hypoxia increases a production of intracellular reactive oxygen species (ROS) (Chandel et al., 2002). ROS can modulate cell signaling through transcription and also through posttranslational modifications of intracellular signaling pathways (Finkel, 2011). Additionally, further mechanisms of low oxygen sensing excluding the involvement of HIF and ROS were reported (Wouters and Korit
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
ED - Fyziologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů