Interactive effect of MTHFR and ADRA2A gene polymorphisms on pathogenesis of schizophrenia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F13%3A00071796" target="_blank" >RIV/00216224:14310/13:00071796 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985904:_____/13:00428603 RIV/61988987:17110/13:A1501A3S

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Interactive effect of MTHFR and ADRA2A gene polymorphisms on pathogenesis of schizophrenia

Popis výsledku v původním jazyce

Increasing evidences support the importance of epigenetic control in schizophrenia pathogenesis. One of the enzymes involved in DNA methylation process through homocysteine metabolism is methylenetetrahydrofolate reductase (MTHFR). The most extensively studied variant in the MTHFR gene is the C677T polymorphism, resulting in reduced enzyme activity and elevated homocysteine level. Methods: In sample of 192 schizophrenics and 213 healthy controls an increasing risk of schizophrenia associated with MTHFR677 CT + TT genotype was found (OR=1.6, P=0.021). Association was also evaluated by considering the C677T polymorphism as an interaction with COMT Val158Met and ADRA2A C-1291G polymorphisms previously associated with schizophrenia risk using a logistic regression analysis. Results: Previous studies of MTHFR*COMT (C677T*Val158Met) interaction in relation to schizophrenia resulted in inconsistent results.

Název v anglickém jazyce

Interactive effect of MTHFR and ADRA2A gene polymorphisms on pathogenesis of schizophrenia

Popis výsledku anglicky

Increasing evidences support the importance of epigenetic control in schizophrenia pathogenesis. One of the enzymes involved in DNA methylation process through homocysteine metabolism is methylenetetrahydrofolate reductase (MTHFR). The most extensively studied variant in the MTHFR gene is the C677T polymorphism, resulting in reduced enzyme activity and elevated homocysteine level. Methods: In sample of 192 schizophrenics and 213 healthy controls an increasing risk of schizophrenia associated with MTHFR677 CT + TT genotype was found (OR=1.6, P=0.021). Association was also evaluated by considering the C677T polymorphism as an interaction with COMT Val158Met and ADRA2A C-1291G polymorphisms previously associated with schizophrenia risk using a logistic regression analysis. Results: Previous studies of MTHFR*COMT (C677T*Val158Met) interaction in relation to schizophrenia resulted in inconsistent results.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT14504" target="_blank" >NT14504: Epidemiologie a genetika schizofrenie</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Svazek periodika

34

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

LU - Lucemburské velkovévodství

Počet stran výsledku

6

Strana od-do

792-797

Kód UT WoS článku

000331786100010

EID výsledku v databázi Scopus

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