Direct N1-monosubstitution of piperazine
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F13%3A00074526" target="_blank" >RIV/00216224:14310/13:00074526 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216224:14310/14:00088826
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
čeština
Název v původním jazyce
Direct N1-monosubstitution of piperazine
Popis výsledku v původním jazyce
We report new methods for the efficient direct N1-monosubstitution of piperazine based on the reaction of piperazine-1-ium cation with different electrophilic agents optionally under catalysis by various metal ions supported on weakly acidic cation-exchanger resin. Starting piperazine-1-ium was generated in situ from piperazine in acetic acid solution or by chemi-sorption of piperazine on weakly acidic cation-exchanger resin (i. e. solid phase synthesis with ionically bonded substrate). These two methods were used for reaction with electrophilic reagents such as acyl chlorides, anhydrides, sulfonyl chlorides, carbamoyl chlorides, for example. For aza-Michael additions of piperazine-1-ium cation to compounds with an activated multiple carbon-carbon bond(derivatives of acrylic, propiolic and acetylenedicarboxylic acid) this cation was generated in methanol solution by mixing of piperazine with piperazine-1,4-diium dichloride in various proportions.
Název v anglickém jazyce
Direct N1-monosubstitution of piperazine
Popis výsledku anglicky
We report new methods for the efficient direct N1-monosubstitution of piperazine based on the reaction of piperazine-1-ium cation with different electrophilic agents optionally under catalysis by various metal ions supported on weakly acidic cation-exchanger resin. Starting piperazine-1-ium was generated in situ from piperazine in acetic acid solution or by chemi-sorption of piperazine on weakly acidic cation-exchanger resin (i. e. solid phase synthesis with ionically bonded substrate). These two methods were used for reaction with electrophilic reagents such as acyl chlorides, anhydrides, sulfonyl chlorides, carbamoyl chlorides, for example. For aza-Michael additions of piperazine-1-ium cation to compounds with an activated multiple carbon-carbon bond(derivatives of acrylic, propiolic and acetylenedicarboxylic acid) this cation was generated in methanol solution by mixing of piperazine with piperazine-1,4-diium dichloride in various proportions.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
CC - Organická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/2A-1TP1%2F090" target="_blank" >2A-1TP1/090: Nové katalyzátory a činidla pro udržitelné zelené syntézy a kombinatoriální syntézy.</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů