Cysteine peptidase inhibitors of helminths

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00073621" target="_blank" >RIV/00216224:14310/14:00073621 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Cysteine peptidase inhibitors of helminths

Popis výsledku v původním jazyce

Investigating the functions of various bioactive molecules produced by parasites expands our understanding of the principles of host-parasite interaction. Several of these compounds were proven to play a key role in a manipulation of the host immune system and thus maximizing the parasite success; among them also the cysteine peptidase inhibitors (CPI) were recorded. Our work is focused on characterization of the properties of CPI expressed by four helminth model species representing four big taxonomicgroups ? Monogenea, Cestoda, Trematoda and Nematoda. Prior to the functional analysis we searched the transcriptomic and/or genomic data of Eudiplozoon nipponicum, Hymenolepis diminuta, Fascioloides magna and Trichinella spiralis for the presence of conserved cystatin domains. We identified distinct families of CPI (stefins, cystatins and kininogens) and observed differences among the studied species. We designed specific/degenerate primers; amplified, cloned and sequenced the selected g

Název v anglickém jazyce

Cysteine peptidase inhibitors of helminths

Popis výsledku anglicky

Investigating the functions of various bioactive molecules produced by parasites expands our understanding of the principles of host-parasite interaction. Several of these compounds were proven to play a key role in a manipulation of the host immune system and thus maximizing the parasite success; among them also the cysteine peptidase inhibitors (CPI) were recorded. Our work is focused on characterization of the properties of CPI expressed by four helminth model species representing four big taxonomicgroups ? Monogenea, Cestoda, Trematoda and Nematoda. Prior to the functional analysis we searched the transcriptomic and/or genomic data of Eudiplozoon nipponicum, Hymenolepis diminuta, Fascioloides magna and Trichinella spiralis for the presence of conserved cystatin domains. We identified distinct families of CPI (stefins, cystatins and kininogens) and observed differences among the studied species. We designed specific/degenerate primers; amplified, cloned and sequenced the selected g

Druh

O - Ostatní výsledky

CEP obor

EG - Zoologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů