Retinoid-like activity and teratogenic effects of cyanobacterial exudates

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00074441" target="_blank" >RIV/00216224:14310/14:00074441 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0166445X14002355" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0166445X14002355</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.aquatox.2014.06.022" target="_blank" >10.1016/j.aquatox.2014.06.022</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Retinoid-like activity and teratogenic effects of cyanobacterial exudates

Popis výsledku v původním jazyce

Given the essential role of retinoids for vertebrate development this has raised concerns about a potential risk for vertebrates exposed to retinoids during cyanobacterial blooms. Our study focuses on extracellular compounds produced by phytoplankton cells (exudates). In order to address the capacity for the production of retinoids or compounds with retinoid-like activity we compared the exudates of ten cyanobacteria and algae using in vitro reporter gene assay. Exudates of three cyanobacterial speciesshowed retinoid-like activity in the range of 269-2265 ng retinoid equivalents (REQ)/L, while there was no detectable activity in exudates of the investigated algal species. The exudates of one green alga (Desmodesmus quadricaudus) and the two cyanobacterial species with greatest REQ levels, Microgstis aeruginosa and Cylindrospermopsis raciborskii, were selected for testing of the potential relation of retinoid-like activity to developmental toxicity in zebrafish embryos.

Název v anglickém jazyce

Retinoid-like activity and teratogenic effects of cyanobacterial exudates

Popis výsledku anglicky

Given the essential role of retinoids for vertebrate development this has raised concerns about a potential risk for vertebrates exposed to retinoids during cyanobacterial blooms. Our study focuses on extracellular compounds produced by phytoplankton cells (exudates). In order to address the capacity for the production of retinoids or compounds with retinoid-like activity we compared the exudates of ten cyanobacteria and algae using in vitro reporter gene assay. Exudates of three cyanobacterial speciesshowed retinoid-like activity in the range of 269-2265 ng retinoid equivalents (REQ)/L, while there was no detectable activity in exudates of the investigated algal species. The exudates of one green alga (Desmodesmus quadricaudus) and the two cyanobacterial species with greatest REQ levels, Microgstis aeruginosa and Cylindrospermopsis raciborskii, were selected for testing of the potential relation of retinoid-like activity to developmental toxicity in zebrafish embryos.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DJ - Znečištění a kontrola vody

OECD FORD obor

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Projekt

<a href="/cs/project/GAP503%2F12%2F0553" target="_blank" >GAP503/12/0553: Metabolity sinic jako potenciální endokrinní disruptory</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Aquatic toxicology

ISSN

0166-445X

e-ISSN

—

Svazek periodika

155

Číslo periodika v rámci svazku

OCTOBER

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

283-290

Kód UT WoS článku

000342245300032

EID výsledku v databázi Scopus

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