Proteomics in investigation of cancer metastasis: Functional and clinical consequences and methodological challenges.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00074977" target="_blank" >RIV/00216224:14310/14:00074977 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00209805:_____/14:#0000504

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1002/pmic.201300264/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/pmic.201300264/abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/pmic.201300264" target="_blank" >10.1002/pmic.201300264</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Proteomics in investigation of cancer metastasis: Functional and clinical consequences and methodological challenges.

Popis výsledku v původním jazyce

Metastases are responsible for most of the cases of death in patients with solid tumors. There is thus an urgent clinical need of better understanding the exact molecular mechanisms and finding novel therapeutics targets and biomarkers of metastatic disease of various tumors. Metastases are formed in a complicated biological process called metastatic cascade. Up to now, proteomics has enabled the identification of number of metastasis-associated proteins and potential biomarkers in cancer tissues, microdissected cells, model systems, and secretomes. Expression profiles and biological role of key proteins were confirmed in verification and functional experiments. This communication reviews these observations and analyses the methodological aspects of the proteomics approaches used. Moreover, it reviews contribution of current proteomics in the field of functional characterization and interactome analysis of proteins involved in various events in metastatic cascade.

Název v anglickém jazyce

Proteomics in investigation of cancer metastasis: Functional and clinical consequences and methodological challenges.

Popis výsledku anglicky

Metastases are responsible for most of the cases of death in patients with solid tumors. There is thus an urgent clinical need of better understanding the exact molecular mechanisms and finding novel therapeutics targets and biomarkers of metastatic disease of various tumors. Metastases are formed in a complicated biological process called metastatic cascade. Up to now, proteomics has enabled the identification of number of metastasis-associated proteins and potential biomarkers in cancer tissues, microdissected cells, model systems, and secretomes. Expression profiles and biological role of key proteins were confirmed in verification and functional experiments. This communication reviews these observations and analyses the methodological aspects of the proteomics approaches used. Moreover, it reviews contribution of current proteomics in the field of functional characterization and interactome analysis of proteins involved in various events in metastatic cascade.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regionální centrum aplikované molekulární onkologie (RECAMO)</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Proteomics

ISSN

1615-9853

e-ISSN

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Svazek periodika

14

Číslo periodika v rámci svazku

4-5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

426-440

Kód UT WoS článku

000332341200008

EID výsledku v databázi Scopus

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