Novel rapid in vitro cytotoxicity test on mammalian cells based on an electrochemical measuring method

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00079358" target="_blank" >RIV/00216224:14310/14:00079358 - isvavai.cz</a>

Výsledek na webu

<a href="http://link.springer.com/article/10.1007%2Fs10800-014-0707-x" target="_blank" >http://link.springer.com/article/10.1007%2Fs10800-014-0707-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10800-014-0707-x" target="_blank" >10.1007/s10800-014-0707-x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Novel rapid in vitro cytotoxicity test on mammalian cells based on an electrochemical measuring method

Popis výsledku v původním jazyce

The proliferation of pharmaceuticals and chemicals and the increasing manufacture of medical goods have made an assessment of their potential toxicological risks to man and the environment indispensable. Hence, a wide range of tests has been developed inorder to generate data on the harmful effects of chemicals and pharmaceuticals on organisms. Initially, toxicological data were commonly collected from tests involving animals; however, on account of ethical objections, they are gradually being replacedby in vitro cytotoxicity tests. In this work, a new in vitro screening method for the determination of cytotoxicity, based on a novel electrochemical bioactivity sensor system, was implemented. The evaluation was based on current-time curves of a potentiostatic measurement proportional to the reduction of mediator molecules by mammalian cells.

Název v anglickém jazyce

Novel rapid in vitro cytotoxicity test on mammalian cells based on an electrochemical measuring method

Popis výsledku anglicky

The proliferation of pharmaceuticals and chemicals and the increasing manufacture of medical goods have made an assessment of their potential toxicological risks to man and the environment indispensable. Hence, a wide range of tests has been developed inorder to generate data on the harmful effects of chemicals and pharmaceuticals on organisms. Initially, toxicological data were commonly collected from tests involving animals; however, on account of ethical objections, they are gradually being replacedby in vitro cytotoxicity tests. In this work, a new in vitro screening method for the determination of cytotoxicity, based on a novel electrochemical bioactivity sensor system, was implemented. The evaluation was based on current-time curves of a potentiostatic measurement proportional to the reduction of mediator molecules by mammalian cells.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

—

Projekt

<a href="/cs/project/LO1214" target="_blank" >LO1214: Centrum pro výzkum toxických látek v prostředí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF APPLIED ELECTROCHEMISTRY

ISSN

0021-891X

e-ISSN

—

Svazek periodika

44

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

935-943

Kód UT WoS článku

000339723500005

EID výsledku v databázi Scopus

—