Deiodinases and thyroid metabolism disruption in teleost fish

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00079395" target="_blank" >RIV/00216224:14310/14:00079395 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0013935114003314" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0013935114003314</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.envres.2014.09.022" target="_blank" >10.1016/j.envres.2014.09.022</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Deiodinases and thyroid metabolism disruption in teleost fish

Popis výsledku v původním jazyce

Many xenobiotic compounds with endocrine disrupting activity have been described since the late eighties. These compounds are able to interact with natural hormone systems and potentially induce deleterious effects in wildlife, notably piscine species. However, while the characterization of endocrine disruptors with "dioxin-like", estrogenic or androgenic activities is relatively well established, little is known about environmentally relevant pollutants that may act at thyroid system level. Iodothyronine deiodinases, the key enzymes in the activation and inactivation of thyroid hormones, have been suggested as suitable biomarkers for thyroid metabolism disruption. The present article reviews the biotic and abiotic factors that are able to modulate deiodinases in teleosts, a representative model organism for vertebrates.

Název v anglickém jazyce

Deiodinases and thyroid metabolism disruption in teleost fish

Popis výsledku anglicky

Many xenobiotic compounds with endocrine disrupting activity have been described since the late eighties. These compounds are able to interact with natural hormone systems and potentially induce deleterious effects in wildlife, notably piscine species. However, while the characterization of endocrine disruptors with "dioxin-like", estrogenic or androgenic activities is relatively well established, little is known about environmentally relevant pollutants that may act at thyroid system level. Iodothyronine deiodinases, the key enzymes in the activation and inactivation of thyroid hormones, have been suggested as suitable biomarkers for thyroid metabolism disruption. The present article reviews the biotic and abiotic factors that are able to modulate deiodinases in teleosts, a representative model organism for vertebrates.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DB - Geologie a mineralogie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Research

ISSN

0013-9351

e-ISSN

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Svazek periodika

135

Číslo periodika v rámci svazku

NOV 2014

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

361-375

Kód UT WoS článku

000346622800048

EID výsledku v databázi Scopus

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