Investigating the amoebicidal activity of Indonesian plant extracts possibly used as medicinal plants by orangutans

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00081110" target="_blank" >RIV/00216224:14310/15:00081110 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.icaac.org/" target="_blank" >http://www.icaac.org/</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Investigating the amoebicidal activity of Indonesian plant extracts possibly used as medicinal plants by orangutans

Popis výsledku v původním jazyce

Presenter?s Email: peterdstuart@hotmail.com Amoebiasis, the condition that results from infection with Entamoeba histolytica, is a major global health concern. Infection is common in the tropics, including South-East Asia. Infection can also occur in non-human primates and most recently has been observed in wild orangutans (Pongo sp.). Plants from Indonesia were selected to be tested for activity against E. histolytica, based on observations that orangutans were consuming them more when infected with parasitic protozoa. Methanol and Methanol:Tetrahydrofuran crude extracts were obtained from four plants: Achidendron fagifollium, Diospyros sumatra, Piper betle and Shorea sumatrana. Of these D. sumatra and P. betle showed activity against E. histolytica (IC50 &lt;47microg/ml and IC50 &lt;67 mikrog/ml respectively). The results support the use of these plants for dysentery by local people. They also demonstrate for the first time, that orangutans may be directly self-medicating.

Název v anglickém jazyce

Investigating the amoebicidal activity of Indonesian plant extracts possibly used as medicinal plants by orangutans

Popis výsledku anglicky

Presenter?s Email: peterdstuart@hotmail.com Amoebiasis, the condition that results from infection with Entamoeba histolytica, is a major global health concern. Infection is common in the tropics, including South-East Asia. Infection can also occur in non-human primates and most recently has been observed in wild orangutans (Pongo sp.). Plants from Indonesia were selected to be tested for activity against E. histolytica, based on observations that orangutans were consuming them more when infected with parasitic protozoa. Methanol and Methanol:Tetrahydrofuran crude extracts were obtained from four plants: Achidendron fagifollium, Diospyros sumatra, Piper betle and Shorea sumatrana. Of these D. sumatra and P. betle showed activity against E. histolytica (IC50 &lt;47microg/ml and IC50 &lt;67 mikrog/ml respectively). The results support the use of these plants for dysentery by local people. They also demonstrate for the first time, that orangutans may be directly self-medicating.

Druh

O - Ostatní výsledky

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

<a href="/cs/project/GAP505%2F11%2F1163" target="_blank" >GAP505/11/1163: Protizánětlivá aktivita extraktů z rostlin Indonésie a jejich účinek na průběh oportunních parazitóz</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů