An experimentally refined tool to assess the risks of the human dermal exposure to herbicide chlorotoluron

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00081592" target="_blank" >RIV/00216224:14310/15:00081592 - isvavai.cz</a>

Výsledek na webu

<a href="http://link.springer.com/article/10.1007%2Fs11356-015-4252-x" target="_blank" >http://link.springer.com/article/10.1007%2Fs11356-015-4252-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11356-015-4252-x" target="_blank" >10.1007/s11356-015-4252-x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

An experimentally refined tool to assess the risks of the human dermal exposure to herbicide chlorotoluron

Popis výsledku v původním jazyce

Dermal absorption of the herbicide chlorotoluron was measured using ex vivo pig skin in Franz diffusion cells in an automated system. The steady-state flux was calculated, as well as the permeability coefficient, which is 0.0038 cm h(-1). The permeability coefficient (K-p) is a key factor when predicting human health risks resulting from dermal exposition to a substance. The experimental determination of this parameter filled data gaps regarding the dermal absorption of chlorotoluron. The experimental permeability coefficient was subsequently used to calculate the dermal absorbed dose during some exposure scenarios. Reference doses were revised, and screening risk assessment process was done to calculate the risks resulting from exposure to chlorotoluron. This refined new approach proved to be a useful tool for human health risk assessment in the areas with these herbicide applications.

Název v anglickém jazyce

An experimentally refined tool to assess the risks of the human dermal exposure to herbicide chlorotoluron

Popis výsledku anglicky

Dermal absorption of the herbicide chlorotoluron was measured using ex vivo pig skin in Franz diffusion cells in an automated system. The steady-state flux was calculated, as well as the permeability coefficient, which is 0.0038 cm h(-1). The permeability coefficient (K-p) is a key factor when predicting human health risks resulting from dermal exposition to a substance. The experimental determination of this parameter filled data gaps regarding the dermal absorption of chlorotoluron. The experimental permeability coefficient was subsequently used to calculate the dermal absorbed dose during some exposure scenarios. Reference doses were revised, and screening risk assessment process was done to calculate the risks resulting from exposure to chlorotoluron. This refined new approach proved to be a useful tool for human health risk assessment in the areas with these herbicide applications.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Science and Pollution Research

ISSN

0944-1344

e-ISSN

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Svazek periodika

22

Číslo periodika v rámci svazku

14

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

10713-10720

Kód UT WoS článku

000357344300033

EID výsledku v databázi Scopus

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