Thermodynamic and Kinetic Study of Mono- and Bis-triazamacrocyclic Ligands and their Transition Metal Complexes Mimicking Hydrolytic Enzyme Activity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00081671" target="_blank" >RIV/00216224:14310/15:00081671 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Thermodynamic and Kinetic Study of Mono- and Bis-triazamacrocyclic Ligands and their Transition Metal Complexes Mimicking Hydrolytic Enzyme Activity

Popis výsledku v původním jazyce

Polyaza-macrocyclic ligands are recently utilized to bind some radioisotopes for application in medicinal chemistry (60?64,67Cu, 66?68Ga, 86,90Y, 111In) [1,2] and the formed metal complexes of high thermodynamic stability and kinetic inertness are required for their use in vivo for medical purposes. Several copper(II) and zinc(II) complexes of bis-polyaza-macrocyclic ligands catalyse some chemical reactions and therefore they can be used as model systems mimicking enzymes activity. In this work, the protonation constants of novel macrocyclic ligands as well as stability constants of their copper(II) and zinc(II) complexes were determined by glass-electrode potentiometry and molecular absorption spectroscopy. The formation of the copper(II) complexes ofboth ligands is accelerated with increased pH. The dissociation of both copper(II) complexes does not differ within experimental error indicating no cooperative effect for binucleating ligand.

Název v anglickém jazyce

Thermodynamic and Kinetic Study of Mono- and Bis-triazamacrocyclic Ligands and their Transition Metal Complexes Mimicking Hydrolytic Enzyme Activity

Popis výsledku anglicky

Polyaza-macrocyclic ligands are recently utilized to bind some radioisotopes for application in medicinal chemistry (60?64,67Cu, 66?68Ga, 86,90Y, 111In) [1,2] and the formed metal complexes of high thermodynamic stability and kinetic inertness are required for their use in vivo for medical purposes. Several copper(II) and zinc(II) complexes of bis-polyaza-macrocyclic ligands catalyse some chemical reactions and therefore they can be used as model systems mimicking enzymes activity. In this work, the protonation constants of novel macrocyclic ligands as well as stability constants of their copper(II) and zinc(II) complexes were determined by glass-electrode potentiometry and molecular absorption spectroscopy. The formation of the copper(II) complexes ofboth ligands is accelerated with increased pH. The dissociation of both copper(II) complexes does not differ within experimental error indicating no cooperative effect for binucleating ligand.

Druh

D - Stať ve sborníku

CEP obor

CA - Anorganická chemie

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Acta of the International Symposia on Metal Complexes ? ISMEC Acta Vol.5 (2015)

ISBN

—

ISSN

2239-2459

e-ISSN

—

Počet stran výsledku

2

Strana od-do

70-71

Název nakladatele

University of Wroclaw

Místo vydání

Wroclaw

Místo konání akce

Wroclaw

Datum konání akce

1. 1. 2015

Typ akce podle státní příslušnosti

CST - Celostátní akce

Kód UT WoS článku

—