The aryl hydrocarbon receptor-dependent disruption of contact inhibition in rat liver WB-F344 epithelial cells is linked with induction of survivin, but not with inhibition of apoptosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00083055" target="_blank" >RIV/00216224:14310/15:00083055 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081707:_____/15:00446223 RIV/61989592:15310/15:33155397 RIV/00027162:_____/15:#0001342

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.tox.2015.04.001" target="_blank" >http://dx.doi.org/10.1016/j.tox.2015.04.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tox.2015.04.001" target="_blank" >10.1016/j.tox.2015.04.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The aryl hydrocarbon receptor-dependent disruption of contact inhibition in rat liver WB-F344 epithelial cells is linked with induction of survivin, but not with inhibition of apoptosis

Popis výsledku v původním jazyce

Inhibition of apoptosis by the ligands of the aryl hydrocarbon receptor (AhR) has been proposed to play a role in their tumor promoting effects on liver parenchymal cells. However, little is presently known about the impact of toxic AhR ligands, such as2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on apoptosis in other liver cell types, such as in liver epithelial/progenitor cells. In the present study, we focused on the effects of TCDD on apoptosis regulation in a model of liver progenitor cells, rat WB-F344 cell line, during the TCDD-elicited release from contact inhibition. The stimulation of cell proliferation in this cell line was associated with deregulated expression of a number of genes known to be under transcriptional control of the Hippo signaling pathway, a principal regulatory pathway involved in contact inhibition of cell proliferation.

Název v anglickém jazyce

The aryl hydrocarbon receptor-dependent disruption of contact inhibition in rat liver WB-F344 epithelial cells is linked with induction of survivin, but not with inhibition of apoptosis

Popis výsledku anglicky

Inhibition of apoptosis by the ligands of the aryl hydrocarbon receptor (AhR) has been proposed to play a role in their tumor promoting effects on liver parenchymal cells. However, little is presently known about the impact of toxic AhR ligands, such as2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on apoptosis in other liver cell types, such as in liver epithelial/progenitor cells. In the present study, we focused on the effects of TCDD on apoptosis regulation in a model of liver progenitor cells, rat WB-F344 cell line, during the TCDD-elicited release from contact inhibition. The stimulation of cell proliferation in this cell line was associated with deregulated expression of a number of genes known to be under transcriptional control of the Hippo signaling pathway, a principal regulatory pathway involved in contact inhibition of cell proliferation.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA13-07711S" target="_blank" >GA13-07711S: Úloha signalizační dráhy Hippo a organických toxikantů v deregulaci funkcí jaterních buněk a metabolismu xenobiotik</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Toxicology

ISSN

0300-483X

e-ISSN

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Svazek periodika

333

Číslo periodika v rámci svazku

July

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

8

Strana od-do

37-44

Kód UT WoS článku

000357228200004

EID výsledku v databázi Scopus

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