Chondrocyte Cultivationi in Hyaluronan-Tyramine Cross-Linked Hydrogel

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00112166" target="_blank" >RIV/00216224:14310/15:00112166 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.tandfonline.com/doi/abs/10.1080/00914037.2014.996715?journalCode=gpom20" target="_blank" >https://www.tandfonline.com/doi/abs/10.1080/00914037.2014.996715?journalCode=gpom20</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/00914037.2014.996715" target="_blank" >10.1080/00914037.2014.996715</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chondrocyte Cultivationi in Hyaluronan-Tyramine Cross-Linked Hydrogel

Popis výsledku v původním jazyce

The application of chondrocyte-seeded hydrogels, such as tyramine-substituted hyaluronan, is a highly promising strategy for damaged cartilage treatments. The rheological characteristics of hyaluronan-tyramine derivative scaffold were determined together with the hydrogel swelling, the water uptake, and the morphological characterization. The chondrocytes seeded in hyaluronan-tyramine hydrogel were viable and expressed markers typical for differentiated chondrocytes with no signs of hypertrophy or extensive expression of matrix metalloproteinases. The lyophilized unseeded hyaluronan-tyramine scaffolds were also implantated into trochlea osteochondral defects in rabbits. In conclusion, the hyaluronan-tyramine derivative was proven to be advisable material as a scaffold for cartilage reconstitution.

Název v anglickém jazyce

Chondrocyte Cultivationi in Hyaluronan-Tyramine Cross-Linked Hydrogel

Popis výsledku anglicky

The application of chondrocyte-seeded hydrogels, such as tyramine-substituted hyaluronan, is a highly promising strategy for damaged cartilage treatments. The rheological characteristics of hyaluronan-tyramine derivative scaffold were determined together with the hydrogel swelling, the water uptake, and the morphological characterization. The chondrocytes seeded in hyaluronan-tyramine hydrogel were viable and expressed markers typical for differentiated chondrocytes with no signs of hypertrophy or extensive expression of matrix metalloproteinases. The lyophilized unseeded hyaluronan-tyramine scaffolds were also implantated into trochlea osteochondral defects in rabbits. In conclusion, the hyaluronan-tyramine derivative was proven to be advisable material as a scaffold for cartilage reconstitution.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS

ISSN

0091-4037

e-ISSN

1563-535X

Svazek periodika

64

Číslo periodika v rámci svazku

13

Stát vydavatele periodika

NO - Norské království

Počet stran výsledku

14

Strana od-do

661-674

Kód UT WoS článku

000352724100001

EID výsledku v databázi Scopus

2-s2.0-84928034696