A new approach to pretreatment of a pencil graphite electrode surface for 3N-methyladenine determination

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A new approach to pretreatment of a pencil graphite electrode surface for 3N-methyladenine determination

Popis výsledku v původním jazyce

Purine derivatives are important molecules in human metabolism. DNA is constantly attacked by many species forming different products such as oxidized forms. Methyl groups have been commonly observed in the case of DNA damage. The purine ring of adenine can be methylated at different positions. So far there have been only few studies of electrochemical behavior aimed at oxidation processes of N-methyladenines. We found out the possibility of measuring 3N-methyladenine (3N-mAde) on a pencil graphite electrode (PeGE) whose surface requires a surface pretreatment. The unique surface morphology of the PeGE, together with adsorption stripping, gives us the opportunity to study 3N-mAde signals. It is noteworthy that there were no 3N-mAde signals at a glassy carbon (GC) electrode at the same experimental conditions.

Název v anglickém jazyce

A new approach to pretreatment of a pencil graphite electrode surface for 3N-methyladenine determination

Popis výsledku anglicky

Purine derivatives are important molecules in human metabolism. DNA is constantly attacked by many species forming different products such as oxidized forms. Methyl groups have been commonly observed in the case of DNA damage. The purine ring of adenine can be methylated at different positions. So far there have been only few studies of electrochemical behavior aimed at oxidation processes of N-methyladenines. We found out the possibility of measuring 3N-methyladenine (3N-mAde) on a pencil graphite electrode (PeGE) whose surface requires a surface pretreatment. The unique surface morphology of the PeGE, together with adsorption stripping, gives us the opportunity to study 3N-mAde signals. It is noteworthy that there were no 3N-mAde signals at a glassy carbon (GC) electrode at the same experimental conditions.

Druh

D - Stať ve sborníku

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

XVI. Workshop of Physical Chemists and Electrochemists

ISBN

9788021082670

ISSN

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e-ISSN

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Počet stran výsledku

5

Strana od-do

149-153

Název nakladatele

Masarykova univerzita

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

6. 6. 2016

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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