Double strand breaks may be a missing link between entropy and aging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F16%3A00090377" target="_blank" >RIV/00216224:14310/16:00090377 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.mad.2016.06.002" target="_blank" >http://dx.doi.org/10.1016/j.mad.2016.06.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mad.2016.06.002" target="_blank" >10.1016/j.mad.2016.06.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Double strand breaks may be a missing link between entropy and aging

Popis výsledku v původním jazyce

It has been previously suggested that an increase in entropy production leads to aging. However, the mechanisms linking increased entropy production in living mass to aging are currently unclear. Even though entropy cannot be easily associated with any specific molecular damage, the increase of entropy in structural mass may be connected with heat stress, which is known to generate double strand breaks. Double strand breaks, which are in turn known to play an important role in process of aging, are thus connected to both aging and an increase of entropy. In view of these associations, we propose a new model where the increase of entropy leads to the formation of double strand breaks, resulting in an aging phenotype. This not only offers a new perspective on aging research and facilitates experimental validation, but could also serve as a useful explanatory tool.

Název v anglickém jazyce

Double strand breaks may be a missing link between entropy and aging

Popis výsledku anglicky

It has been previously suggested that an increase in entropy production leads to aging. However, the mechanisms linking increased entropy production in living mass to aging are currently unclear. Even though entropy cannot be easily associated with any specific molecular damage, the increase of entropy in structural mass may be connected with heat stress, which is known to generate double strand breaks. Double strand breaks, which are in turn known to play an important role in process of aging, are thus connected to both aging and an increase of entropy. In view of these associations, we propose a new model where the increase of entropy leads to the formation of double strand breaks, resulting in an aging phenotype. This not only offers a new perspective on aging research and facilitates experimental validation, but could also serve as a useful explanatory tool.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/LM2011028" target="_blank" >LM2011028: RECETOX ? Národní infrastruktura pro výzkum toxických látek v prostředí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mechanisms of Ageing and Development

ISSN

0047-6374

e-ISSN

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Svazek periodika

157

Číslo periodika v rámci svazku

July

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

6

Strana od-do

1-6

Kód UT WoS článku

000383303000001

EID výsledku v databázi Scopus

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