SYNTHESIS OF FRAGRANCES STARTING FROM CYCLIC VINYL KETONES

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F16%3A00108440" target="_blank" >RIV/00216224:14310/16:00108440 - isvavai.cz</a>

Výsledek na webu

<a href="https://sciforum.net/paper/view/conference/3648" target="_blank" >https://sciforum.net/paper/view/conference/3648</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ecsoc-20-a056" target="_blank" >10.3390/ecsoc-20-a056</a>

Jazyk výsledku

angličtina

Název v původním jazyce

SYNTHESIS OF FRAGRANCES STARTING FROM CYCLIC VINYL KETONES

Popis výsledku v původním jazyce

Synthesis of fragrances, i.e. methyl esters and lactones of cyclic ketones, starts from cyclic vinyl ketones. These react with hydrogen cyanide in the presence of basic catalyst. Formed keto nitriles undergo a reduction of keto group in secondary hydroxy group in the next steps and process is followed by functionalization of cyano group in carboxy or alkoxycarbonyl group. The order of both processes can be exchanged. The final lactonization carry out between hydroxy and (funcionalized) carboxy group under acidic conditions.The functionalization of cyano group and subsequent lactonization take place as a one-pot process. This innovative process is simpler and cheaper and provides products in very good yields and purity, which allows further processing in the synthesis of the final products.

Název v anglickém jazyce

SYNTHESIS OF FRAGRANCES STARTING FROM CYCLIC VINYL KETONES

Popis výsledku anglicky

Synthesis of fragrances, i.e. methyl esters and lactones of cyclic ketones, starts from cyclic vinyl ketones. These react with hydrogen cyanide in the presence of basic catalyst. Formed keto nitriles undergo a reduction of keto group in secondary hydroxy group in the next steps and process is followed by functionalization of cyano group in carboxy or alkoxycarbonyl group. The order of both processes can be exchanged. The final lactonization carry out between hydroxy and (funcionalized) carboxy group under acidic conditions.The functionalization of cyano group and subsequent lactonization take place as a one-pot process. This innovative process is simpler and cheaper and provides products in very good yields and purity, which allows further processing in the synthesis of the final products.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

<a href="/cs/project/TA03010633" target="_blank" >TA03010633: Progresivní udržitelné technologie pro syntézy chemických specialit z oblasti kyanové chemie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů