Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F17%3A00100126" target="_blank" >RIV/00216224:14310/17:00100126 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319849/pdf/nihms847486.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319849/pdf/nihms847486.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.amepre.2016.09.026" target="_blank" >10.1016/j.amepre.2016.09.026</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination

Popis výsledku v původním jazyce

Introduction: This study investigates social determinants of systemic inflammation, focusing on race, SES, and perceived discrimination. Methods: Data on 884 white and 170 black participants were obtained from the Survey of Midlife in the U.S., a cross-sectional observational study combining survey measures, anthropometry, and biomarker assay. Data, collected in 2004-2009, were analyzed in 2016. Main outcome measures were fasting blood concentrations of C-reactive protein, interleukin 6, fibrinogen, and E-selectin. For each biomarker, series of multivariate linear regression models were estimated for the pooled sample and separately for blacks and whites. Full models included social determinants; psychological, lifestyle, and health factors; and demographic covariates. Results: Bivariate analyses indicated higher concentrations of all inflammation markers among blacks compared with whites (p &lt; 0.001). In fully adjusted models using the pooled sample, racial differences persisted for interleukin 6 (p &lt; 0.001) and fibrinogen (p &lt; 0.01). For E-selectin and C-reactive protein, racial differences were explained after adjusting for covariates. Education was linked to lower fibrinogen concentration (p &lt; 0.05) in the fully adjusted model and C-reactive protein concentration (p &lt; 0.01) after adjusting for demographic factors and income. Lifetime perceived discrimination was related to higher concentrations of fibrinogen (p &lt; 0.05) in the fully adjusted model, and higher concentrations of E-selectin and interleukin 6 (p &lt; 0.05) after adjusting for socioeconomic status (SES) and demographic factors. Conclusions: This study clarifies the contributions of race, SES, and perceived discrimination to inflammation. It suggests that inflammation-reducing interventions should focus on blacks and individuals facing socioeconomic disadvantages, especially low education.

Název v anglickém jazyce

Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination

Popis výsledku anglicky

Introduction: This study investigates social determinants of systemic inflammation, focusing on race, SES, and perceived discrimination. Methods: Data on 884 white and 170 black participants were obtained from the Survey of Midlife in the U.S., a cross-sectional observational study combining survey measures, anthropometry, and biomarker assay. Data, collected in 2004-2009, were analyzed in 2016. Main outcome measures were fasting blood concentrations of C-reactive protein, interleukin 6, fibrinogen, and E-selectin. For each biomarker, series of multivariate linear regression models were estimated for the pooled sample and separately for blacks and whites. Full models included social determinants; psychological, lifestyle, and health factors; and demographic covariates. Results: Bivariate analyses indicated higher concentrations of all inflammation markers among blacks compared with whites (p &lt; 0.001). In fully adjusted models using the pooled sample, racial differences persisted for interleukin 6 (p &lt; 0.001) and fibrinogen (p &lt; 0.01). For E-selectin and C-reactive protein, racial differences were explained after adjusting for covariates. Education was linked to lower fibrinogen concentration (p &lt; 0.05) in the fully adjusted model and C-reactive protein concentration (p &lt; 0.01) after adjusting for demographic factors and income. Lifetime perceived discrimination was related to higher concentrations of fibrinogen (p &lt; 0.05) in the fully adjusted model, and higher concentrations of E-selectin and interleukin 6 (p &lt; 0.05) after adjusting for socioeconomic status (SES) and demographic factors. Conclusions: This study clarifies the contributions of race, SES, and perceived discrimination to inflammation. It suggests that inflammation-reducing interventions should focus on blacks and individuals facing socioeconomic disadvantages, especially low education.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30304 - Public and environmental health

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

AMERICAN JOURNAL OF PREVENTIVE MEDICINE

ISSN

0749-3797

e-ISSN

—

Svazek periodika

52

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

„S63“-„S76“

Kód UT WoS článku

000390667100009

EID výsledku v databázi Scopus

2-s2.0-85008146356