FireProt 1.0

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F17%3A00100360" target="_blank" >RIV/00216224:14310/17:00100360 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

FireProt 1.0

Popis výsledku v původním jazyce

FireProt is a web server for an automated design of thermostable mutants. The design of thermostable mutants is based on the integration of structural and evolutionary information obtained from several bioinformatics databases and computational tools. FireProt strategy combines energy- and evolution-based approaches together with several filters that accelerate the calculation by omitting potentially deleterious mutations. Within its workflow, FireProt integrates 16 computational tools, utilizing both sequence and structural information in the process. FireProt web server provides users with a one-stop-shop solution for the design of thermostable proteins, constructed by three distinct strategies: (i) evolution-based approach, utilizing back-to-consensus analysis; (ii) energy-based approach, using conservation, correlation and energy information and (iii) combined approach. Furthermore, the server allows users to include user-defined mutations into the constructed thermostable protein and generate corresponding sequences in the FASTA format. The results are visualized in the web browser in an intuitive and comprehensive way, allowing users to directly analyze the designed proteins.

Název v anglickém jazyce

FireProt 1.0

Popis výsledku anglicky

FireProt is a web server for an automated design of thermostable mutants. The design of thermostable mutants is based on the integration of structural and evolutionary information obtained from several bioinformatics databases and computational tools. FireProt strategy combines energy- and evolution-based approaches together with several filters that accelerate the calculation by omitting potentially deleterious mutations. Within its workflow, FireProt integrates 16 computational tools, utilizing both sequence and structural information in the process. FireProt web server provides users with a one-stop-shop solution for the design of thermostable proteins, constructed by three distinct strategies: (i) evolution-based approach, utilizing back-to-consensus analysis; (ii) energy-based approach, using conservation, correlation and energy information and (iii) combined approach. Furthermore, the server allows users to include user-defined mutations into the constructed thermostable protein and generate corresponding sequences in the FASTA format. The results are visualized in the web browser in an intuitive and comprehensive way, allowing users to directly analyze the designed proteins.

Druh

R - Software

CEP obor

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OECD FORD obor

10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Interní identifikační kód produktu

FireProt 1.0

Technické parametry

licenční smlouva není uzavřená

Ekonomické parametry

zvýšení ročního obratu

IČO vlastníka výsledku

00216224

Název vlastníka

MU