Ferrocenes as Potential Anticancer Drugs: Determination of The Mechanism of Action
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F18%3A00103342" target="_blank" >RIV/00216224:14310/18:00103342 - isvavai.cz</a>
Výsledek na webu
—
DOI - Digital Object Identifier
—
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Ferrocenes as Potential Anticancer Drugs: Determination of The Mechanism of Action
Popis výsledku v původním jazyce
A series of ferrocene derivatives bearing either substituted or unsubstituted saturated five- and sixmembered nitrogen-containing heterocycles was synthesized. Some of these compounds showed clear cytotoxicity towards ovarian cancer cells in doses comparable to or even lower than Cisplatin, treatment of choice for ovarian cancer. The most promising ferrocene derivative was chosen to determine the mechanism of action inside SK-OV-3 cells. We used differential pulse voltammetry to measure low levels of accumulated drugs, which identified transferrin receptors as prominent transporters of ferrocenes. The important part of our work also consists in determining the mode of action consisting predominately in production of reactive oxygen species inside the cancer cells.
Název v anglickém jazyce
Ferrocenes as Potential Anticancer Drugs: Determination of The Mechanism of Action
Popis výsledku anglicky
A series of ferrocene derivatives bearing either substituted or unsubstituted saturated five- and sixmembered nitrogen-containing heterocycles was synthesized. Some of these compounds showed clear cytotoxicity towards ovarian cancer cells in doses comparable to or even lower than Cisplatin, treatment of choice for ovarian cancer. The most promising ferrocene derivative was chosen to determine the mechanism of action inside SK-OV-3 cells. We used differential pulse voltammetry to measure low levels of accumulated drugs, which identified transferrin receptors as prominent transporters of ferrocenes. The important part of our work also consists in determining the mode of action consisting predominately in production of reactive oxygen species inside the cancer cells.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
—
OECD FORD obor
10608 - Biochemistry and molecular biology
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů