Are we approaching a post-monolithic era?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F20%3A00114433" target="_blank" >RIV/00216224:14310/20:00114433 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1002/jssc.201901331" target="_blank" >https://doi.org/10.1002/jssc.201901331</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jssc.201901331" target="_blank" >10.1002/jssc.201901331</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Are we approaching a post-monolithic era?

Popis výsledku v původním jazyce

Thirty years after their introduction, monolithic stationary phases are an important member of chromatographic phases. When compared to conventional particulate materials, the continuous internal structure of both inorganic silica and organic polymer monoliths allows some hydrodynamic and analytical possibilities that are not provided by conventional particulate stationary phases. Polymer-based monolithic stationary phases offer simple preparation and straightforward surface modification, which makes them very versatile materials that are applicable, for example, as chromatographic stationary phases, sample enrichment units, enzymatic reactors, and external trigger-responding materials. On the other hand, current polymer monoliths cannot compete with efficiency provided by superficially porous and sub 2 mu m particles. In this highlight article, I take advantage of the 30th anniversary of their introduction to discuss several concerns related to polymer-based monolithic stationary phases. Particularly, I focus on preparation repeatability, porous properties, swelling of the polymers in organic solvents, column efficiency for small molecules, and heterogeneity of dominant flow-through pores. In the end, I offer three possible approaches on how to overcome drawbacks related to stationary phases heterogeneity to further increase the applicability of polymer-based monolithic stationary phases.

Název v anglickém jazyce

Are we approaching a post-monolithic era?

Popis výsledku anglicky

Thirty years after their introduction, monolithic stationary phases are an important member of chromatographic phases. When compared to conventional particulate materials, the continuous internal structure of both inorganic silica and organic polymer monoliths allows some hydrodynamic and analytical possibilities that are not provided by conventional particulate stationary phases. Polymer-based monolithic stationary phases offer simple preparation and straightforward surface modification, which makes them very versatile materials that are applicable, for example, as chromatographic stationary phases, sample enrichment units, enzymatic reactors, and external trigger-responding materials. On the other hand, current polymer monoliths cannot compete with efficiency provided by superficially porous and sub 2 mu m particles. In this highlight article, I take advantage of the 30th anniversary of their introduction to discuss several concerns related to polymer-based monolithic stationary phases. Particularly, I focus on preparation repeatability, porous properties, swelling of the polymers in organic solvents, column efficiency for small molecules, and heterogeneity of dominant flow-through pores. In the end, I offer three possible approaches on how to overcome drawbacks related to stationary phases heterogeneity to further increase the applicability of polymer-based monolithic stationary phases.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

<a href="/cs/project/GA17-11252S" target="_blank" >GA17-11252S: Polymerní monolitické stacionární fáze s kontrolovanou selektivitou</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of separation science

ISSN

1615-9306

e-ISSN

1615-9314

Svazek periodika

43

Číslo periodika v rámci svazku

9-10

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

6

Strana od-do

1628-1633

Kód UT WoS článku

000512026000001

EID výsledku v databázi Scopus

2-s2.0-85079479713