Modulation of Differentiation of Embryonic Stem Cells by Polypyrrole: The Impact on Neurogenesis
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F21%3A00118907" target="_blank" >RIV/00216224:14310/21:00118907 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/61389013:_____/21:00537040
Výsledek na webu
<a href="https://doi.org/10.3390/ijms22020501" target="_blank" >https://doi.org/10.3390/ijms22020501</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms22020501" target="_blank" >10.3390/ijms22020501</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Modulation of Differentiation of Embryonic Stem Cells by Polypyrrole: The Impact on Neurogenesis
Popis výsledku v původním jazyce
The active role of biomaterials in the regeneration of tissues and their ability to modulate the behavior of stem cells in terms of their differentiation is highly advantageous. Here, polypyrrole, as a representantive of electro-conducting materials, is found to modulate the behavior of embryonic stem cells. Concretely, the aqueous extracts of polypyrrole induce neurogenesis within embryonic bodies formed from embryonic stem cells. This finding ledto an effort to determine the physiological cascade which is responsible for this effect. The polypyrrole modulates signaling pathways of Akt and ERK kinase through their phosphorylation. These effects are related to the presence of low-molecular-weight compounds present in aqueous polypyrrole extracts, determined by mass spectroscopy. The results show that consequences related to the modulation of stem cell differentiation must also be taken into account when polypyrrole is considered as a biomaterial.
Název v anglickém jazyce
Modulation of Differentiation of Embryonic Stem Cells by Polypyrrole: The Impact on Neurogenesis
Popis výsledku anglicky
The active role of biomaterials in the regeneration of tissues and their ability to modulate the behavior of stem cells in terms of their differentiation is highly advantageous. Here, polypyrrole, as a representantive of electro-conducting materials, is found to modulate the behavior of embryonic stem cells. Concretely, the aqueous extracts of polypyrrole induce neurogenesis within embryonic bodies formed from embryonic stem cells. This finding ledto an effort to determine the physiological cascade which is responsible for this effect. The polypyrrole modulates signaling pathways of Akt and ERK kinase through their phosphorylation. These effects are related to the presence of low-molecular-weight compounds present in aqueous polypyrrole extracts, determined by mass spectroscopy. The results show that consequences related to the modulation of stem cell differentiation must also be taken into account when polypyrrole is considered as a biomaterial.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10608 - Biochemistry and molecular biology
Návaznosti výsledku
Projekt
<a href="/cs/project/GA19-16861S" target="_blank" >GA19-16861S: Interakce biomateriálů s kmenovými buňkami v simulovaných in vivo podmínkách</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
1422-0067
Svazek periodika
22
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
CH - Švýcarská konfederace
Počet stran výsledku
17
Strana od-do
„501“
Kód UT WoS článku
000611321200001
EID výsledku v databázi Scopus
2-s2.0-85099135097