Associations between Per- and Polyfluoroalkyl Substances (PFAS) and Cardiometabolic Biomarkers in Adults of Czechia: The Kardiovize Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F22%3A00127465" target="_blank" >RIV/00216224:14310/22:00127465 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/22:00078558

Výsledek na webu

<a href="https://www.mdpi.com/1660-4601/19/21/13898" target="_blank" >https://www.mdpi.com/1660-4601/19/21/13898</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijerph192113898" target="_blank" >10.3390/ijerph192113898</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Associations between Per- and Polyfluoroalkyl Substances (PFAS) and Cardiometabolic Biomarkers in Adults of Czechia: The Kardiovize Study

Popis výsledku v původním jazyce

Even though there is evidence of decreasing trends of per- and polyfluoroalkyl substances (PFAS) in Czechia, there are still major sources of PFAS pollution. Regarding the still-inconsistent results of the relationship between cardiometabolic health and PFAS, the present study sought to determine the association between PFAS levels and the presence of cardiometabolic biomarkers, including blood pressure and dysglycemia drivers in the Czech population. A cross-sectional study with 479 subjects (56.4% women, median: 53 years, range: 25-89) was conducted. Four PFAS were measured in serum: perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluorooctane sulfonate (PFOS). The associations between natural log (ln)-transformed PFAS and cardiometabolic biomarkers were assessed through generalized additive models using linear regression and smoothing thin plate splines, adjusted for potential confounders. There were positive and significant (p &lt; 0.05) associations between the ln-transformed PFOA and glucose (beta = 0.01), systolic (beta = 0.76) and diastolic blood pressure (beta = 0.65); total cholesterol (beta = 0.07) and LDL-c (beta = 0.04); and PFOS with glucose (beta = 0.03), BMI (beta = 2.26), waist circumference (beta = 7.89), systolic blood pressure (beta = 1.18), total cholesterol (beta = 0.13), and HDL-c (beta = 0.04). When significant, the correlations of PFNA and PFDA were negative. Of the four PFAS, only PFOA and PFOS showed a positive association, even in serum levels not as high as the values from the literature.

Název v anglickém jazyce

Associations between Per- and Polyfluoroalkyl Substances (PFAS) and Cardiometabolic Biomarkers in Adults of Czechia: The Kardiovize Study

Popis výsledku anglicky

Even though there is evidence of decreasing trends of per- and polyfluoroalkyl substances (PFAS) in Czechia, there are still major sources of PFAS pollution. Regarding the still-inconsistent results of the relationship between cardiometabolic health and PFAS, the present study sought to determine the association between PFAS levels and the presence of cardiometabolic biomarkers, including blood pressure and dysglycemia drivers in the Czech population. A cross-sectional study with 479 subjects (56.4% women, median: 53 years, range: 25-89) was conducted. Four PFAS were measured in serum: perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluorooctane sulfonate (PFOS). The associations between natural log (ln)-transformed PFAS and cardiometabolic biomarkers were assessed through generalized additive models using linear regression and smoothing thin plate splines, adjusted for potential confounders. There were positive and significant (p &lt; 0.05) associations between the ln-transformed PFOA and glucose (beta = 0.01), systolic (beta = 0.76) and diastolic blood pressure (beta = 0.65); total cholesterol (beta = 0.07) and LDL-c (beta = 0.04); and PFOS with glucose (beta = 0.03), BMI (beta = 2.26), waist circumference (beta = 7.89), systolic blood pressure (beta = 1.18), total cholesterol (beta = 0.13), and HDL-c (beta = 0.04). When significant, the correlations of PFNA and PFDA were negative. Of the four PFAS, only PFOA and PFOS showed a positive association, even in serum levels not as high as the values from the literature.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30304 - Public and environmental health

Projekt

<a href="/cs/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molekulární, buněčný a klinický přístup ke zdravému stárnutí</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Environmental Research and Public Health

ISSN

1660-4601

e-ISSN

1660-4601

Svazek periodika

19

Číslo periodika v rámci svazku

21

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

10

Strana od-do

1-10

Kód UT WoS článku

000881134300001

EID výsledku v databázi Scopus

2-s2.0-85141629095