How error-prone bioaccumulation experiments affect the risk assessment of hydrophobic chemicals and what could be improved

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F23%3A00131194" target="_blank" >RIV/00216224:14310/23:00131194 - isvavai.cz</a>

Výsledek na webu

<a href="https://setac.onlinelibrary.wiley.com/doi/10.1002/ieam.4714" target="_blank" >https://setac.onlinelibrary.wiley.com/doi/10.1002/ieam.4714</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ieam.4714" target="_blank" >10.1002/ieam.4714</a>

Jazyk výsledku

angličtina

Název v původním jazyce

How error-prone bioaccumulation experiments affect the risk assessment of hydrophobic chemicals and what could be improved

Popis výsledku v původním jazyce

Bioaccumulation is one of the three criteria for the PBT assessment of chemicals, where P stands for persistence, B for bioaccumulation, and T for toxicity, which is a cornerstone for the “Registration, Evaluation, Authorization, and Restriction of Chemicals” (REACH) in the EU. Registrants are required by REACH to submit data on bioaccumulation if the chemical is manufactured in and/or imported to the European Economic Area at more than 100 t/year. Most of the experimental bioaccumulation studies submitted were on the bioconcentration factor (BCF) and were conducted prior to 2012, before the OECD Test Guideline 305 on Bioaccumulation in Fish was updated. An analysis of the submitted data revealed that many of the experimental data, but also the data from QSARs and other calculation methods, underestimate the actual bioaccumulation potential of hydrophobic substances considerably. One of the main reasons in the nonexperimental studies is that the BCF is related there to the total concentration of the chemical in water and not to the dissolved chemical concentration. There is therefore an urgent need to reassess the bioaccumulation potential of the hydrophobic substances registered under REACH. Based on the model calculations in the present study, between 332 and 584 substances that are registered under REACH are likely to bioaccumulate in the aquatic environment—many more than have so far been identified in the B assessment. Integr Environ Assess Manag 2023;19:792–803.

Název v anglickém jazyce

How error-prone bioaccumulation experiments affect the risk assessment of hydrophobic chemicals and what could be improved

Popis výsledku anglicky

Bioaccumulation is one of the three criteria for the PBT assessment of chemicals, where P stands for persistence, B for bioaccumulation, and T for toxicity, which is a cornerstone for the “Registration, Evaluation, Authorization, and Restriction of Chemicals” (REACH) in the EU. Registrants are required by REACH to submit data on bioaccumulation if the chemical is manufactured in and/or imported to the European Economic Area at more than 100 t/year. Most of the experimental bioaccumulation studies submitted were on the bioconcentration factor (BCF) and were conducted prior to 2012, before the OECD Test Guideline 305 on Bioaccumulation in Fish was updated. An analysis of the submitted data revealed that many of the experimental data, but also the data from QSARs and other calculation methods, underestimate the actual bioaccumulation potential of hydrophobic substances considerably. One of the main reasons in the nonexperimental studies is that the BCF is related there to the total concentration of the chemical in water and not to the dissolved chemical concentration. There is therefore an urgent need to reassess the bioaccumulation potential of the hydrophobic substances registered under REACH. Based on the model calculations in the present study, between 332 and 584 substances that are registered under REACH are likely to bioaccumulate in the aquatic environment—many more than have so far been identified in the B assessment. Integr Environ Assess Manag 2023;19:792–803.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30108 - Toxicology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Integrated Environmental Assessment and Management

ISSN

1551-3777

e-ISSN

—

Svazek periodika

19

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

792-803

Kód UT WoS článku

000897858500001

EID výsledku v databázi Scopus

2-s2.0-85144130847