Effects of N-(Alkoxyphenyl)-1-hydroxynaphthalene-2-carboxamides on Intestinal Microbial Communities

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F23%3A00132340" target="_blank" >RIV/00216224:14310/23:00132340 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.3390/ecsoc-27-16142" target="_blank" >https://doi.org/10.3390/ecsoc-27-16142</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ecsoc-27-16142" target="_blank" >10.3390/ecsoc-27-16142</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of N-(Alkoxyphenyl)-1-hydroxynaphthalene-2-carboxamides on Intestinal Microbial Communities

Popis výsledku v původním jazyce

The phylum Proteobacteria, more precisely the family Enterobacteriacea, has been shown to be a major cause of inflammation in the human microbiome. Their standard level in the human intestine is usually kept below 1% in a healthy person, and their overgrowth above this number leads to intestinal inflammation, which can cause the development of inflammatory bowel diseases - most often Crohn's disease or ulcerative colitis. The minimum inhibitory concentrations (MICs) of a series of eighteen recently synthesized N-(alkoxyphenyl)-2-hydroxynaphthalene-1-carboxamides were determined against two representatives of the Enterobacteriaceae family – Escherichia coli CCM 3954 and Salmonella typhimurium LT 2-18. Although the tested compounds are cyclic analogs of salicylanilides known to have strong antimicrobial properties, the minimum inhibitory concentrations found were in the range between 50 µM and 1000 µM. However, it can be concluded that S. typhimurium was generally more sensitive to the tested antimicrobial agents than E .coli. N-[2-(But-2-yloxy)phenyl]-1-hydroxynaphthalene-2-carboxamide was the most active of the compounds with an MIC of 100 µM against pro E. coli and an MIC of 50 µM against S. typhimurium.

Název v anglickém jazyce

Effects of N-(Alkoxyphenyl)-1-hydroxynaphthalene-2-carboxamides on Intestinal Microbial Communities

Popis výsledku anglicky

The phylum Proteobacteria, more precisely the family Enterobacteriacea, has been shown to be a major cause of inflammation in the human microbiome. Their standard level in the human intestine is usually kept below 1% in a healthy person, and their overgrowth above this number leads to intestinal inflammation, which can cause the development of inflammatory bowel diseases - most often Crohn's disease or ulcerative colitis. The minimum inhibitory concentrations (MICs) of a series of eighteen recently synthesized N-(alkoxyphenyl)-2-hydroxynaphthalene-1-carboxamides were determined against two representatives of the Enterobacteriaceae family – Escherichia coli CCM 3954 and Salmonella typhimurium LT 2-18. Although the tested compounds are cyclic analogs of salicylanilides known to have strong antimicrobial properties, the minimum inhibitory concentrations found were in the range between 50 µM and 1000 µM. However, it can be concluded that S. typhimurium was generally more sensitive to the tested antimicrobial agents than E .coli. N-[2-(But-2-yloxy)phenyl]-1-hydroxynaphthalene-2-carboxamide was the most active of the compounds with an MIC of 100 µM against pro E. coli and an MIC of 50 µM against S. typhimurium.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

The 27th International Electronic Conference on Synthetic Organic Chemistry

ISBN

—

ISSN

2673-4583

e-ISSN

2673-4583

Počet stran výsledku

5

Strana od-do

1-5

Název nakladatele

MDPI

Místo vydání

Basel

Místo konání akce

on-line, Basel, Švýcarsko

Datum konání akce

15. 11. 2023

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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