Direct detection methods for monitoring of therapeutic staphylococcal bacteriophages in clinical samples

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F23%3A00132459" target="_blank" >RIV/00216224:14310/23:00132459 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Direct detection methods for monitoring of therapeutic staphylococcal bacteriophages in clinical samples

Popis výsledku v původním jazyce

The most promising alternative for effectively treating infections caused by Staphylococcus aureus is the application of therapeutic bacteriophages of the genus Kayvirus. Although the genomic properties of phages are well-studied, new findings are emerging on the pharmacokinetic profiling of phage drugs. The significant factors relevant to the therapeutic use of phages include i) optimal dosing, ii) duration of exposure to phages, iii) absence of phage genes for toxins and virulence factors, and iv) selection of phages suitable for the infectious agent1. Currently, there is a lack of methods for capturing and monitoring phages in clinical material. Our study aims to develop a technique for a sufficiently sensitive method for the detection and quantification of phage particles in different types of clinical material during phage therapy and clinical trials.

Název v anglickém jazyce

Direct detection methods for monitoring of therapeutic staphylococcal bacteriophages in clinical samples

Popis výsledku anglicky

The most promising alternative for effectively treating infections caused by Staphylococcus aureus is the application of therapeutic bacteriophages of the genus Kayvirus. Although the genomic properties of phages are well-studied, new findings are emerging on the pharmacokinetic profiling of phage drugs. The significant factors relevant to the therapeutic use of phages include i) optimal dosing, ii) duration of exposure to phages, iii) absence of phage genes for toxins and virulence factors, and iv) selection of phages suitable for the infectious agent1. Currently, there is a lack of methods for capturing and monitoring phages in clinical material. Our study aims to develop a technique for a sufficiently sensitive method for the detection and quantification of phage particles in different types of clinical material during phage therapy and clinical trials.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10606 - Microbiology

Projekt

<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů