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The effect of intrapartum antibiotics prophylaxis on oral bacteriome in neonates in the first week of theri life - i pilot study

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F23%3A00133530" target="_blank" >RIV/00216224:14310/23:00133530 - isvavai.cz</a>

  • Výsledek na webu

  • DOI - Digital Object Identifier

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    The effect of intrapartum antibiotics prophylaxis on oral bacteriome in neonates in the first week of theri life - i pilot study

  • Popis výsledku v původním jazyce

    Background: The administration of intrapartum antibiotics prophylaxis (IAP) is commonly used for the prevention of early-onset Group-B-streptococci (GBS) infection. IAP may influence the oral microbiome in neonates. Our study aimed to compare the oral bacteriome between neonates grouped according to their exposure to antibiotics during the delivery and sampling time in the first week of their life. Methods: In this case-control study, oral samples were collected from healthy neonates (n=66) from the CELSPAC:TNG cohort during their hospital stay. The neonates were classified into the group of those delivered by C-section or vaginally with IAP (n=33) and the control group of neonates delivered vaginally without IAP (n=33). The bacteriome profile was determined by 16S rDNA sequencing based on the V3-V4 hyper-variable region. The effect of IAP was tested separately for samples collected within 48 hours of delivery and for those collected later.   Results: Differences in alpha diversity (Shannon index, p=0.01) and bacterial composition (p=0.04, PERMANOVA) were observed in oral samples collected within 48 hours after birth, while bacteriomes in oral samples collected later were similar between IAP and control groups. The genera Streptococcus, Gemella, and Rothia dominated in the oral samples in all groups. Of individual genera, only the relative abundance of Gemella was significantly lower in samples collected within 48 hours after birth in neonates compared to the IAP group (q=0.08). Conclusion: Our results illustrate the effect of IAP on oral bacteriome of neonates within the 48 hours after birth. However, this effect seems to be suppressed during the first week of their life.

  • Název v anglickém jazyce

    The effect of intrapartum antibiotics prophylaxis on oral bacteriome in neonates in the first week of theri life - i pilot study

  • Popis výsledku anglicky

    Background: The administration of intrapartum antibiotics prophylaxis (IAP) is commonly used for the prevention of early-onset Group-B-streptococci (GBS) infection. IAP may influence the oral microbiome in neonates. Our study aimed to compare the oral bacteriome between neonates grouped according to their exposure to antibiotics during the delivery and sampling time in the first week of their life. Methods: In this case-control study, oral samples were collected from healthy neonates (n=66) from the CELSPAC:TNG cohort during their hospital stay. The neonates were classified into the group of those delivered by C-section or vaginally with IAP (n=33) and the control group of neonates delivered vaginally without IAP (n=33). The bacteriome profile was determined by 16S rDNA sequencing based on the V3-V4 hyper-variable region. The effect of IAP was tested separately for samples collected within 48 hours of delivery and for those collected later.   Results: Differences in alpha diversity (Shannon index, p=0.01) and bacterial composition (p=0.04, PERMANOVA) were observed in oral samples collected within 48 hours after birth, while bacteriomes in oral samples collected later were similar between IAP and control groups. The genera Streptococcus, Gemella, and Rothia dominated in the oral samples in all groups. Of individual genera, only the relative abundance of Gemella was significantly lower in samples collected within 48 hours after birth in neonates compared to the IAP group (q=0.08). Conclusion: Our results illustrate the effect of IAP on oral bacteriome of neonates within the 48 hours after birth. However, this effect seems to be suppressed during the first week of their life.

Klasifikace

  • Druh

    O - Ostatní výsledky

  • CEP obor

  • OECD FORD obor

    10608 - Biochemistry and molecular biology

Návaznosti výsledku

  • Projekt

    Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Ostatní

  • Rok uplatnění

    2023

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů