Vitamin B12 intake during pregnancy linked to child speech development and intelligence quotient

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F25%3A00140431" target="_blank" >RIV/00216224:14310/25:00140431 - isvavai.cz</a>

Výsledek na webu

<a href="https://academic.oup.com/jpubhealth/advance-article/doi/10.1093/pubmed/fdae307/7923983" target="_blank" >https://academic.oup.com/jpubhealth/advance-article/doi/10.1093/pubmed/fdae307/7923983</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/pubmed/fdae307" target="_blank" >10.1093/pubmed/fdae307</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Vitamin B12 intake during pregnancy linked to child speech development and intelligence quotient

Popis výsledku v původním jazyce

Background Nutrient deficiencies during pregnancy may affect offspring development. We aim to examine the association between prenatal vitamin B12 intake and children’s cognitive development. Methods A total of 5151 mother–child pairs from the Czech part of ELSPAC study were included in the analysis. Dietary information was obtained during pregnancy using food frequency questionnaire. Parents reported on their child’s speech and language development at 18 months, 3, 5 and 7 years. Intelligence quotient (IQ) was measured at 8 years in subcohort of 854 children. Results Children of mothers with higher vitamin B12 intake demonstrated higher scores in language (B = 0.20, 95% CI 0.06, 0.34) and talking and understanding (B = 2.39, 95% CI 0.97, 3.80) in a fully adjusted model at 18 months. Additionally, they were more likely to get maximum points in the intelligibility test at age 3 (OR = 1.05, 95% CI 1.01, 1.09) in unadjusted model, however, not in fully adjusted model. We found a positive effect of higher vitamin B12 intake on verbal IQ (B = 1.08, 95% CI 0.09, 2.08). Conclusions We identified consistent associations between prenatal vitamin B12 intake and children’s cognitive development. The results suggest that inadequate vitamin B12 during pregnancy may negatively affect children’s cognitive development, particularly in speech and language.

Název v anglickém jazyce

Vitamin B12 intake during pregnancy linked to child speech development and intelligence quotient

Popis výsledku anglicky

Background Nutrient deficiencies during pregnancy may affect offspring development. We aim to examine the association between prenatal vitamin B12 intake and children’s cognitive development. Methods A total of 5151 mother–child pairs from the Czech part of ELSPAC study were included in the analysis. Dietary information was obtained during pregnancy using food frequency questionnaire. Parents reported on their child’s speech and language development at 18 months, 3, 5 and 7 years. Intelligence quotient (IQ) was measured at 8 years in subcohort of 854 children. Results Children of mothers with higher vitamin B12 intake demonstrated higher scores in language (B = 0.20, 95% CI 0.06, 0.34) and talking and understanding (B = 2.39, 95% CI 0.97, 3.80) in a fully adjusted model at 18 months. Additionally, they were more likely to get maximum points in the intelligibility test at age 3 (OR = 1.05, 95% CI 1.01, 1.09) in unadjusted model, however, not in fully adjusted model. We found a positive effect of higher vitamin B12 intake on verbal IQ (B = 1.08, 95% CI 0.09, 2.08). Conclusions We identified consistent associations between prenatal vitamin B12 intake and children’s cognitive development. The results suggest that inadequate vitamin B12 during pregnancy may negatively affect children’s cognitive development, particularly in speech and language.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30304 - Public and environmental health

Projekt

<a href="/cs/project/LX22NPO5101" target="_blank" >LX22NPO5101: Národní institut pro výzkum socioekonomických dopadů nemocí a systémových rizik</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF PUBLIC HEALTH

ISSN

1741-3842

e-ISSN

1741-3850

Svazek periodika

47

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

34-44

Kód UT WoS článku

001377198500001

EID výsledku v databázi Scopus

2-s2.0-86000143403