Biomarker responses in wild brown trout from a headwater stream and their causal link to water pollution assessed through chemical analysis and in vitro reporter gene bioassays

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F25%3A00141581" target="_blank" >RIV/00216224:14310/25:00141581 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12520/25:43909697

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0304389425013482?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0304389425013482?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jhazmat.2025.138433" target="_blank" >10.1016/j.jhazmat.2025.138433</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Biomarker responses in wild brown trout from a headwater stream and their causal link to water pollution assessed through chemical analysis and in vitro reporter gene bioassays

Popis výsledku v původním jazyce

Improving our understanding of how environmental pollution affects aquatic life requires a holistic approach. This study provides new insights into the intrinsic biological defence of brown trout (Salmo trutta m. fario L.) against chemical pollution in a stream with a low-dilution factor, a common scenario in headwaters globally. Fish restocked downstream of a sewage treatment plant (STP) were compared with a control group upstream of STP. Trout tissues were sampled after 6, 14, and 24 weeks and subjected to biochemical and histological analyses. Passive samplers were deployed at both stream stretches to reflect concentrations of freely dissolved organic micropollutants and their bioactivity effects using in vitro reporter gene bioassays. Chemical analysis downstream revealed elevated concentrations of micropollutants compared to upstream. In vitro bioassays detected increased androgenicity, estrogenicity, and transthyretin-binding inhibition. Antioxidant and biotransformation enzyme activities in fish indicated gradual acclimation to pollution despite minor histopathological changes. Elevated vitellogenin and 17 beta-estradiol in males suggested pollution-induced endocrine disruption. Although the results obtained from water chemical profiling and bioassays have a causal relationship to fish health, trout's molecular defence system allowed gradual acclimation to pollution, mitigating broader ecological impacts. The study advanced the knowledge of how fish cope with wastewater-borne micropollutants in aquatic environments. vitellogenin and 17 beta-estradiol in males suggested pollution-induced endocrine disruption. Although the results obtained from water chemical profiling and bioassays have a causal relationship to fish health, trout's molecular defence system allowed gradual acclimation to pollution, mitigating broader ecological impacts. The study advanced the knowledge of how fish cope with wastewater-borne micropollutants in aquatic environments.

Název v anglickém jazyce

Biomarker responses in wild brown trout from a headwater stream and their causal link to water pollution assessed through chemical analysis and in vitro reporter gene bioassays

Popis výsledku anglicky

Improving our understanding of how environmental pollution affects aquatic life requires a holistic approach. This study provides new insights into the intrinsic biological defence of brown trout (Salmo trutta m. fario L.) against chemical pollution in a stream with a low-dilution factor, a common scenario in headwaters globally. Fish restocked downstream of a sewage treatment plant (STP) were compared with a control group upstream of STP. Trout tissues were sampled after 6, 14, and 24 weeks and subjected to biochemical and histological analyses. Passive samplers were deployed at both stream stretches to reflect concentrations of freely dissolved organic micropollutants and their bioactivity effects using in vitro reporter gene bioassays. Chemical analysis downstream revealed elevated concentrations of micropollutants compared to upstream. In vitro bioassays detected increased androgenicity, estrogenicity, and transthyretin-binding inhibition. Antioxidant and biotransformation enzyme activities in fish indicated gradual acclimation to pollution despite minor histopathological changes. Elevated vitellogenin and 17 beta-estradiol in males suggested pollution-induced endocrine disruption. Although the results obtained from water chemical profiling and bioassays have a causal relationship to fish health, trout's molecular defence system allowed gradual acclimation to pollution, mitigating broader ecological impacts. The study advanced the knowledge of how fish cope with wastewater-borne micropollutants in aquatic environments. vitellogenin and 17 beta-estradiol in males suggested pollution-induced endocrine disruption. Although the results obtained from water chemical profiling and bioassays have a causal relationship to fish health, trout's molecular defence system allowed gradual acclimation to pollution, mitigating broader ecological impacts. The study advanced the knowledge of how fish cope with wastewater-borne micropollutants in aquatic environments.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10511 - Environmental sciences (social aspects to be 5.7)

Projekt

<a href="/cs/project/GX20-04676X" target="_blank" >GX20-04676X: Holistická charakterizace expozice a potenciálních účinků komplexních směsí chemických látek ve vodním prostředí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Hazardous Materials

ISSN

0304-3894

e-ISSN

1873-3336

Svazek periodika

494

Číslo periodika v rámci svazku

August 2025

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

19

Strana od-do

1-19

Kód UT WoS článku

001485930700002

EID výsledku v databázi Scopus

2-s2.0-105004175406