Comparison of pharmacodynamic and pharmacokinetic aspects in systemic and local infection during phage therapy in a murine model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F25%3A00143293" target="_blank" >RIV/00216224:14310/25:00143293 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Comparison of pharmacodynamic and pharmacokinetic aspects in systemic and local infection during phage therapy in a murine model

Popis výsledku v původním jazyce

Although the use of bacteriophages to treat bacterial infections has a long history, and the growing international crisis of resistance to standard antibiotics encourages alternative treatment approaches, phage therapy is not currently used as a standard medical approach. One explanation for why phage therapy has not been widely adopted in clinical practice is that pharmacological data on preclinical and clinical testing of phages are still lacking. Our study compares the pharmacological aspects of phage therapy in a murine model of open wound, where systemic infection occurs, and in a murine model of abscess, which simulates local infection.

Název v anglickém jazyce

Comparison of pharmacodynamic and pharmacokinetic aspects in systemic and local infection during phage therapy in a murine model

Popis výsledku anglicky

Although the use of bacteriophages to treat bacterial infections has a long history, and the growing international crisis of resistance to standard antibiotics encourages alternative treatment approaches, phage therapy is not currently used as a standard medical approach. One explanation for why phage therapy has not been widely adopted in clinical practice is that pharmacological data on preclinical and clinical testing of phages are still lacking. Our study compares the pharmacological aspects of phage therapy in a murine model of open wound, where systemic infection occurs, and in a murine model of abscess, which simulates local infection.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10600 - Biological sciences

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů