Insights into Infant Strongyloidiasis, Papua New Guinea

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F25%3A00143384" target="_blank" >RIV/00216224:14310/25:00143384 - isvavai.cz</a>

Výsledek na webu

<a href="https://wwwnc.cdc.gov/eid/article/31/9/24-1923_article" target="_blank" >https://wwwnc.cdc.gov/eid/article/31/9/24-1923_article</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3201/eid3109.241923" target="_blank" >10.3201/eid3109.241923</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Insights into Infant Strongyloidiasis, Papua New Guinea

Popis výsledku v původním jazyce

The human-infecting parasite Strongyloides fuelleborni subspecies kellyi has been reported from the island of New Guinea. We analyzed fecal DNA extracts (n = 164) from 19 infants in Papua New Guinea by using Strongyloides real-time PCR and undertook metabarcoding of cox1 and 18S rRNA hypervariable regions I and IV loci. Eight infants were infected with Strongyloides spp.; 7 were infected with S. fuelleborni subsp. fuelleborni and 1 with a Strongyloides sp. previously misattributed to S. fuelleborni subsp. kellyi. Phylogenetic and haplotyping analyses indicated S. fuelleborni in Papua New Guinea belongs to the Indochina subclade of S. fuelleborni subsp. fuelleborni and is not a unique subspecies. We report molecular evidence of S. fuelleborni subsp. fuelleborni infection in humans in the Pacific. Our findings also demonstrate the potential co-existence of an undescribed human-infecting Strongyloides sp. on the island of New Guinea, indicating a need for renewed clinical and epidemiologic investigations into infant strongyloidiasis.

Název v anglickém jazyce

Insights into Infant Strongyloidiasis, Papua New Guinea

Popis výsledku anglicky

The human-infecting parasite Strongyloides fuelleborni subspecies kellyi has been reported from the island of New Guinea. We analyzed fecal DNA extracts (n = 164) from 19 infants in Papua New Guinea by using Strongyloides real-time PCR and undertook metabarcoding of cox1 and 18S rRNA hypervariable regions I and IV loci. Eight infants were infected with Strongyloides spp.; 7 were infected with S. fuelleborni subsp. fuelleborni and 1 with a Strongyloides sp. previously misattributed to S. fuelleborni subsp. kellyi. Phylogenetic and haplotyping analyses indicated S. fuelleborni in Papua New Guinea belongs to the Indochina subclade of S. fuelleborni subsp. fuelleborni and is not a unique subspecies. We report molecular evidence of S. fuelleborni subsp. fuelleborni infection in humans in the Pacific. Our findings also demonstrate the potential co-existence of an undescribed human-infecting Strongyloides sp. on the island of New Guinea, indicating a need for renewed clinical and epidemiologic investigations into infant strongyloidiasis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40301 - Veterinary science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

EMERGING INFECTIOUS DISEASES

ISSN

1080-6040

e-ISSN

1080-6059

Svazek periodika

31

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

1793-1801

Kód UT WoS článku

001614308300013

EID výsledku v databázi Scopus

2-s2.0-105015049873