Dendritic Cell Biology anf the Application of Dendritic Cells to Imunotherapy of Multiple Myeloma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F00%3A00004077" target="_blank" >RIV/00216224:14330/00:00004077 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Dendritic Cell Biology anf the Application of Dendritic Cells to Imunotherapy of Multiple Myeloma

Popis výsledku v původním jazyce

Dentritic cells (DCs)are extremely efficient antigen-presenting cells that arepotent stimulators of both B and T cell immune responses. Although DCc are normally present in extremely small numbers in the circulation, recent advances in DC biology have made it possible to generale DCs in culture. DCs can be generated in vitro from various cellular sources including bone marrow, cor blood and peripheral blood. Although culture conditions are extremely diverse, the majority of protocols grow DCs in GM-CSFand either TNF-aplha and/or IL. The addition of other growth factors such as SCF and Flt-3 ligand can dramatically enhance DC recovery. It is important to appereciate that DC subsets have been identified. Thus, DC at different stages of maturation, basedon phenotype and capacity to capture antigen, can be obtained depending on culture conditions. For clinical applications, DCs can be generated in serum-free median and cryopreserved for future cclinical applications. The ability to obtai

Název v anglickém jazyce

Dendritic Cell Biology anf the Application of Dendritic Cells to Imunotherapy of Multiple Myeloma

Popis výsledku anglicky

Dentritic cells (DCs)are extremely efficient antigen-presenting cells that arepotent stimulators of both B and T cell immune responses. Although DCc are normally present in extremely small numbers in the circulation, recent advances in DC biology have made it possible to generale DCs in culture. DCs can be generated in vitro from various cellular sources including bone marrow, cor blood and peripheral blood. Although culture conditions are extremely diverse, the majority of protocols grow DCs in GM-CSFand either TNF-aplha and/or IL. The addition of other growth factors such as SCF and Flt-3 ligand can dramatically enhance DC recovery. It is important to appereciate that DC subsets have been identified. Thus, DC at different stages of maturation, basedon phenotype and capacity to capture antigen, can be obtained depending on culture conditions. For clinical applications, DCs can be generated in serum-free median and cryopreserved for future cclinical applications. The ability to obtai

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/NC6152" target="_blank" >NC6152: Hodnocení léčebného efektu dentrických buněk u nemocných s mnohočetným myelomem.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2000

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Medical Oncology

ISSN

1357-0560

e-ISSN

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Svazek periodika

2000

Číslo periodika v rámci svazku

17

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

2-15

Kód UT WoS článku

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EID výsledku v databázi Scopus

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