SUV39h- and A-type Lamin-Dependent Telomere Nuclear Rearrangement

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F10%3A00051236" target="_blank" >RIV/00216224:14330/10:00051236 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1002/jcb.22466/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/jcb.22466/abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jcb.22466" target="_blank" >10.1002/jcb.22466</a>

Jazyk výsledku

angličtina

Název v původním jazyce

SUV39h- and A-type Lamin-Dependent Telomere Nuclear Rearrangement

Popis výsledku v původním jazyce

Telomeres are specialized chromatin structures that are situated at the end of linear chromosomes and play an important role in cell senescence and immortalization. Here, we investigated whether changes in histone signature influence the nuclear arrangement and positioning of telomeres. Analysis of mouse embryonic fibroblasts revealed that telomeres were organized into specific clusters that partially associated with centromeric clusters. This nuclear arrangement was influenced by deficiency of the histone methyltransferase SUV39h, LMNA deficiency, and the histone deacetylase inhibitor Trichostatin A (TSA). Similarly, nuclear radial distributions of telomeric clusters were preferentially influenced by TSA, which caused relocation of telomeres closer tothe nuclear center. Telomeres also co-localized with promyelocytic leukemia bodies. This association was increased by SUV39h deficiency and decreased by LMNA deficiency.

Název v anglickém jazyce

SUV39h- and A-type Lamin-Dependent Telomere Nuclear Rearrangement

Popis výsledku anglicky

Telomeres are specialized chromatin structures that are situated at the end of linear chromosomes and play an important role in cell senescence and immortalization. Here, we investigated whether changes in histone signature influence the nuclear arrangement and positioning of telomeres. Analysis of mouse embryonic fibroblasts revealed that telomeres were organized into specific clusters that partially associated with centromeric clusters. This nuclear arrangement was influenced by deficiency of the histone methyltransferase SUV39h, LMNA deficiency, and the histone deacetylase inhibitor Trichostatin A (TSA). Similarly, nuclear radial distributions of telomeric clusters were preferentially influenced by TSA, which caused relocation of telomeres closer tothe nuclear center. Telomeres also co-localized with promyelocytic leukemia bodies. This association was increased by SUV39h deficiency and decreased by LMNA deficiency.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Cellular Biochemistry

ISSN

0730-2312

e-ISSN

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Svazek periodika

109

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

915-926

Kód UT WoS článku

000276418900010

EID výsledku v databázi Scopus

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