Influence of circadian clocks on optimal regime of central C-N metabolism of cyanobacteria

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F18%3A00104828" target="_blank" >RIV/00216224:14330/18:00104828 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/86652079:_____/19:00497586

Výsledek na webu

<a href="https://doi.org/10.1016/B978-0-12-814667-5.00009-X" target="_blank" >https://doi.org/10.1016/B978-0-12-814667-5.00009-X</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-814667-5.00009-X" target="_blank" >10.1016/B978-0-12-814667-5.00009-X</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Influence of circadian clocks on optimal regime of central C-N metabolism of cyanobacteria

Popis výsledku v původním jazyce

Mechanistic aspects of cyanobacteria clock and metabolism have been analyzed in considerable detail during recent decades, but only limited knowledge is available about particular link(s) between the clock and controlled metabolic processes. We describe a case study where we couple a mechanistic model of a circadian oscillator with a model of central carbon-nitrogen metabolism and apply formal methods based on temporal logic and bifurcation analysis to examine response of the metabolic part of the combined model to the autonomous clock oscillations. The analysis identified a set of parametric groups that, when applied to the in silico system, lead either to an optimal configuration of metabolic pathways for most efficient rhythmic function of the metabolism or to (oscillatory) system death. Under controlled conditions in monitored environments, such as cultivation in photobioreactors, the knowledge can be used for optimal regulation of production capacity that would reflect dynamic constraints of real world systems.

Název v anglickém jazyce

Influence of circadian clocks on optimal regime of central C-N metabolism of cyanobacteria

Popis výsledku anglicky

Mechanistic aspects of cyanobacteria clock and metabolism have been analyzed in considerable detail during recent decades, but only limited knowledge is available about particular link(s) between the clock and controlled metabolic processes. We describe a case study where we couple a mechanistic model of a circadian oscillator with a model of central carbon-nitrogen metabolism and apply formal methods based on temporal logic and bifurcation analysis to examine response of the metabolic part of the combined model to the autonomous clock oscillations. The analysis identified a set of parametric groups that, when applied to the in silico system, lead either to an optimal configuration of metabolic pathways for most efficient rhythmic function of the metabolism or to (oscillatory) system death. Under controlled conditions in monitored environments, such as cultivation in photobioreactors, the knowledge can be used for optimal regulation of production capacity that would reflect dynamic constraints of real world systems.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

20900 - Industrial biotechnology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Cyanobacteria: From Basic Science to Applications

ISBN

9780128146675

Počet stran výsledku

14

Strana od-do

193-206

Počet stran knihy

522

Název nakladatele

Academic Press

Místo vydání

Neuveden

Kód UT WoS kapitoly

000509547100010