Analysis of Biomolecules through Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Employing Nanomaterials

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F11%3A00050122" target="_blank" >RIV/00216224:14740/11:00050122 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/jccs.201190120" target="_blank" >http://dx.doi.org/10.1002/jccs.201190120</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jccs.201190120" target="_blank" >10.1002/jccs.201190120</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Analysis of Biomolecules through Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Employing Nanomaterials

Popis výsledku v původním jazyce

Nanomaterials, primarily nanoparticles (NPs), can serve as an alternative matrix for the analysis of various biomolecules through SALDI MS. SALDI MS has been developed to overcome poor reproducibility and high background in the low mass region commonly occurring in MALDI MS. Various nanomaterials, unmodified or functionalized with recognition ligands, can have a strong affinity toward certain analytes and thus are applicable for their concentration and enrichment from complex biological matrices. In mass spectrometry imaging (MSI), the use of NPs instead of the conventional matrices can improve the spatial resolution up to the cellular level. In this review, the nature of NPs, the methods of sample preparation and approaches for quantitation of biomolecules through SALDI MS are discussed. Practical applications and limitations of SALDI MS employing NPs for separate samples and MSI are mentioned.

Název v anglickém jazyce

Analysis of Biomolecules through Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Employing Nanomaterials

Popis výsledku anglicky

Nanomaterials, primarily nanoparticles (NPs), can serve as an alternative matrix for the analysis of various biomolecules through SALDI MS. SALDI MS has been developed to overcome poor reproducibility and high background in the low mass region commonly occurring in MALDI MS. Various nanomaterials, unmodified or functionalized with recognition ligands, can have a strong affinity toward certain analytes and thus are applicable for their concentration and enrichment from complex biological matrices. In mass spectrometry imaging (MSI), the use of NPs instead of the conventional matrices can improve the spatial resolution up to the cellular level. In this review, the nature of NPs, the methods of sample preparation and approaches for quantitation of biomolecules through SALDI MS are discussed. Practical applications and limitations of SALDI MS employing NPs for separate samples and MSI are mentioned.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the Chinese Chemical Society

ISSN

0009-4536

e-ISSN

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Svazek periodika

58

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

TW - Čínská republika (Tchaj-wan)

Počet stran výsledku

10

Strana od-do

769-778

Kód UT WoS článku

000296267600009

EID výsledku v databázi Scopus

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