The effects of methamphetamine self-administration on behavioural sensitization in the olfactory bulbectomy rat model of depression
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F12%3A00059286" target="_blank" >RIV/00216224:14740/12:00059286 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/62157124:16170/12:43870308
Výsledek na webu
<a href="http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8704767" target="_blank" >http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8704767</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1017/S1461145711001684" target="_blank" >10.1017/S1461145711001684</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The effects of methamphetamine self-administration on behavioural sensitization in the olfactory bulbectomy rat model of depression
Popis výsledku v původním jazyce
Depression is frequently comorbid with a drug addiction and may seriously complicate its treatment. Currently, there is no routinely used animal model to investigate this comorbidity. In this study the effect of repeated administration of methamphetamineon i.v. drug self-administration in an olfactory bulbectomy model of depression in rats was investigated in order to propose and validate a rat model of comorbid depression and addiction. Male Wistar rats were either olfactory-bulbectomized (OBX) or sham-operated. They subsequently underwent a methamphetamine sensitization regime, which consisted of daily i.p. injections of methamphetamine for a 14-d period; controls received Sal injections at the same frequency. The i.v. self-administration of methamphetamine (0.08 mg/kg in one infusion) paradigm on a fixed ratio schedule of reinforcement was performed using operant chambers.
Název v anglickém jazyce
The effects of methamphetamine self-administration on behavioural sensitization in the olfactory bulbectomy rat model of depression
Popis výsledku anglicky
Depression is frequently comorbid with a drug addiction and may seriously complicate its treatment. Currently, there is no routinely used animal model to investigate this comorbidity. In this study the effect of repeated administration of methamphetamineon i.v. drug self-administration in an olfactory bulbectomy model of depression in rats was investigated in order to propose and validate a rat model of comorbid depression and addiction. Male Wistar rats were either olfactory-bulbectomized (OBX) or sham-operated. They subsequently underwent a methamphetamine sensitization regime, which consisted of daily i.p. injections of methamphetamine for a 14-d period; controls received Sal injections at the same frequency. The i.v. self-administration of methamphetamine (0.08 mg/kg in one infusion) paradigm on a fixed ratio schedule of reinforcement was performed using operant chambers.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FH - Neurologie, neurochirurgie, neurovědy
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
The International Journal of Neuropsychopharmacology
ISSN
1461-1457
e-ISSN
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Svazek periodika
15
Číslo periodika v rámci svazku
10
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
9
Strana od-do
1503-1511
Kód UT WoS článku
000309740200011
EID výsledku v databázi Scopus
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