Problematic glycosyltransferase Rv3782 from Mycobacterium tuberculosis and its production in new expression system

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F12%3A00060507" target="_blank" >RIV/00216224:14740/12:00060507 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Problematic glycosyltransferase Rv3782 from Mycobacterium tuberculosis and its production in new expression system

Popis výsledku v původním jazyce

Mycobacterium tuberculosis is germ causing one of the most difficultly treated and in many cases lethal infectious disease ? tuberculosis. This pathogenic bacterium is characterized by unique cell envelope ? dominant feature of M. tuberculosis and othermycobacterial pathogens and crucial factor of virulence and resistance against toxic insult, such as antibiotics and components of the macrophage's bactericidal arsenal. The synthesis of this mycobacterial cell wall is mediated by dominating group of enzymes ? glycosyltransferases. Rv3782 is mycobacterial glycosyltransferase which is responsible for synthesis of mycobacterial galactan - very important element of mycobacterial cell wall and its lack can cause growth inhibition up to death. Due to its role in the cell wall synthesis, the Rv3782 galactofuranosyltransferase may represent very attractive target for new drug development against tuberculosis.

Název v anglickém jazyce

Problematic glycosyltransferase Rv3782 from Mycobacterium tuberculosis and its production in new expression system

Popis výsledku anglicky

Mycobacterium tuberculosis is germ causing one of the most difficultly treated and in many cases lethal infectious disease ? tuberculosis. This pathogenic bacterium is characterized by unique cell envelope ? dominant feature of M. tuberculosis and othermycobacterial pathogens and crucial factor of virulence and resistance against toxic insult, such as antibiotics and components of the macrophage's bactericidal arsenal. The synthesis of this mycobacterial cell wall is mediated by dominating group of enzymes ? glycosyltransferases. Rv3782 is mycobacterial glycosyltransferase which is responsible for synthesis of mycobacterial galactan - very important element of mycobacterial cell wall and its lack can cause growth inhibition up to death. Due to its role in the cell wall synthesis, the Rv3782 galactofuranosyltransferase may represent very attractive target for new drug development against tuberculosis.

Druh

O - Ostatní výsledky

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů